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New insights and long-term safety of tocilizumab in rheumatoid arthritis
Citation
Jones, G and Panova, E, New insights and long-term safety of tocilizumab in rheumatoid arthritis, Therapeutic Advances in Musculoskeletal Disease, 10, (10) pp. 195-199. ISSN 1759-720X (2018) [Refereed Article]
Copyright Statement
Copyright 2018 The Authors
DOI: doi:10.1177/1759720X18798462
Abstract
Rheumatoid arthritis is a leading musculoskeletal cause of disability in Western society. Therapeutic options have expanded rapidly with the advent of biological agents as treatment options. One of these, tocilizumab, targets the interleukin-6 receptor and has been approved since the late 2000s in many jurisdictions. This approval was based on 6-12 month trials. It is now appropriate to look at longer-term studies and what new insights they have provided into this agent. Data are based largely on observational studies with their well-known limitations as well as some further randomized trials and provide a number of important observations regarding both efficacy and safety. In conclusion, the longer-term data suggest tocilizumab efficacy increases over time for both signs and symptoms and radiographic change. It is also corticosteroid sparing. The safety data are consistent with the shorter-term trials and are largely reassuring but some questions still remain over cardiovascular safety and cancer risk.
Item Details
Item Type: | Refereed Article |
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Keywords: | cohort, database, long term, rheumatoid, tocilizumab, trials |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Jones, G (Professor Graeme Jones) |
UTAS Author: | Panova, E (Mrs Elena Panova) |
ID Code: | 130370 |
Year Published: | 2018 |
Web of Science® Times Cited: | 12 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2019-01-23 |
Last Modified: | 2019-12-03 |
Downloads: | 0 |
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