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New insights and long-term safety of tocilizumab in rheumatoid arthritis

Citation

Jones, G and Panova, E, New insights and long-term safety of tocilizumab in rheumatoid arthritis, Therapeutic Advances in Musculoskeletal Disease, 10, (10) pp. 195-199. ISSN 1759-720X (2018) [Refereed Article]

Copyright Statement

Copyright 2018 The Authors

DOI: doi:10.1177/1759720X18798462

Abstract

Rheumatoid arthritis is a leading musculoskeletal cause of disability in Western society. Therapeutic options have expanded rapidly with the advent of biological agents as treatment options. One of these, tocilizumab, targets the interleukin-6 receptor and has been approved since the late 2000s in many jurisdictions. This approval was based on 6-12 month trials. It is now appropriate to look at longer-term studies and what new insights they have provided into this agent. Data are based largely on observational studies with their well-known limitations as well as some further randomized trials and provide a number of important observations regarding both efficacy and safety. In conclusion, the longer-term data suggest tocilizumab efficacy increases over time for both signs and symptoms and radiographic change. It is also corticosteroid sparing. The safety data are consistent with the shorter-term trials and are largely reassuring but some questions still remain over cardiovascular safety and cancer risk.

Item Details

Item Type:Refereed Article
Keywords:cohort, database, long term, rheumatoid, tocilizumab, trials
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Panova, E (Mrs Elena Panova)
ID Code:130370
Year Published:2018
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-01-23
Last Modified:2019-09-09
Downloads:0

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