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Are the metabolic benefits of resistance training in type 2 diabetes linked to improvements in adipose tissue microvascular blood flow?
Citation
Hu, D and Russell, RD and Remash, D and Greenaway, T and Rattigan, S and Squibb, KA and Jones, G and Ross, RM and Roberts, CK and Premilovac, D and Richards, SM and Keske, MA, Are the metabolic benefits of resistance training in type 2 diabetes linked to improvements in adipose tissue microvascular blood flow?, American Journal of Physiology: Endocrinology and Metabolism, 315, (6) pp. E1242-E1250. ISSN 0193-1849 (2018) [Refereed Article]
Copyright Statement
Copyright 2018 APS
DOI: doi:10.1152/ajpendo.00234.2018
Abstract
The microcirculation in adipose tissue is markedly impaired in type 2 diabetes (T2D). Resistance training (RT) often increases muscle mass and promotes a favourable metabolic profile in people with T2D, even in the absence of fat loss. Whether the metabolic benefits of RT in T2D are linked to improvements in adipose tissue microvascular blood flow is unknown. Eighteen sedentary people with T2D (7F/11M, 52±7 years) completed six weeks of RT. Before and after RT, overnight-fasted participants had blood sampled for clinical chemistries (glucose, insulin, lipids, HbA1c and pro-inflammatory markers), underwent an oral glucose challenge (OGC, 50g glucose x 2hr) and a DEXA scan to assess body composition. Adipose tissue microvascular blood volume and flow were assessed at rest and 1hr post-OGC using contrast-enhanced ultrasound. RT significantly reduced fasting blood glucose (p=0.006), HbA1c (p=0.007), 2-hr glucose area under the time curve post-OGC (p=0.014) and HOMA-IR (p=0.005). This was accompanied by a small reduction in total body fat (p=0.002), trunk fat (p=0.023) and fasting triglyceride levels (p=0.029). Lean mass (p=0.003), circulating TNFa (p=0.006) and soluble VCAM-1 (p<0.001) increased post-RT. There were no significant changes in adipose tissue microvascular blood volume of flow following RT, however those who did have a higher baseline MBF post-RT also had lower fasting triglyceride levels (r=-0.476, p=0.045). The anthropometric, glycemic and insulin sensitizing benefits of six weeks of RT in people with T2D are not associated with an improvement in adipose tissue microvascular responses, however there may be an adipose tissue microvascular-linked benefit to fasting triglyceride levels.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | adipose tissue, exercise, metabolic physiology, microvascular blood flow, type 2 diabetes |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Endocrinology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Hu, D (Mr Donghua Hu) |
| UTAS Author: | Russell, RD (Dr Ryan Russell) |
| UTAS Author: | Remash, D (Ms Devika Remash) |
| UTAS Author: | Greenaway, T (Dr Tim Greenaway) |
| UTAS Author: | Rattigan, S (Professor Stephen Rattigan) |
| UTAS Author: | Squibb, KA (Dr Kathryn Squibb) |
| UTAS Author: | Jones, G (Professor Graeme Jones) |
| UTAS Author: | Ross, RM (Dr Renee Ross) |
| UTAS Author: | Premilovac, D (Dr Dino Premilovac) |
| UTAS Author: | Richards, SM (Dr Stephen Richards) |
| UTAS Author: | Keske, MA (Dr Michelle Keske) |
| ID Code: | 130184 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 1 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2019-01-15 |
| Last Modified: | 2019-03-18 |
| Downloads: | 0 |
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