Twenty years after his death, Deleuze’s thought continues to be mobilised in relation to the most timely and critical problems society faces, foremost amongst which is the Anthropocene. What might the significance of Deleuze and Guattari be in relation to the new and urgent set of concerns that the Anthropocene engenders? Deleuze’s work presaged much of the concept of the Anthropocene, not only in his sustained challenges to humanism, anthropocentrism and capitalism, but also through his interest in geology and the philosophy of time. Guattari gave his work an ‘ecosophical’ and ‘cartographical’ dimension and spoke of a ‘mechanosphere’ covering the planet. Together, Deleuze and Guattari advocated a ‘geophilosophy’ which called for a ‘new earth’ along with ‘new peoples’. Not only does the work of Deleuze and Guattari offer a range of useful concepts that can be applied to contemporary global problems such as anthropogenic climate change, peak oil and the exploitation of the nonhuman, but it also models the kind of interdisciplinarity that the epoch of the Anthropocene requires. This special issue of Deleuze Studies will engage the many philosophical tools provided by Deleuze and Guattari and their interlocutors in order to critically approach our particularly tense moment in terrestrial history. Simultaneously it asks how this moment could change the ways Deleuze and Guattari are further developed.