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Patellar tendon enthesis abnormalities and their association with knee pain and structural abnormalities in older adults

Citation

Mattap, SM and Aitken, D and Wills, K and Halliday, A and Ding, C and Han, W and Munugoda, I and Graves, SE and Lorimer, M and Cicuttini, F and Jones, G and Laslett, LL, Patellar tendon enthesis abnormalities and their association with knee pain and structural abnormalities in older adults, Osteoarthritis and Cartilage, 27, (3) pp. 449-458. ISSN 1063-4584 (2018) [Refereed Article]


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Copyright Statement

Copyright 2018 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2018.11.009

Abstract

Objective: To describe associations between presence of patellar tendon enthesis (PTE) abnormalities and symptoms, structural abnormalities, and total knee replacement (TKR) in older adult cohort.

Methods: PTE abnormalities (presence of abnormal bone signal and/or bone erosion), were measured on T2-weighted magnetic resonance (MR) images at baseline in 961 community-dwelling older adults. Knee pain and function limitation were assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Bone marrow lesions (BMLs), cartilage volume and defects score, and infrapatellar fat pad (IPFP) area were measured using validated methods. Incidence of TKR was determined by data linkage.

Results: Participants with abnormal PTE bone signal and/or erosion was 20%. Cross-sectionally, presence of PTE abnormalities was associated with greater pain intensity while going up and down stairs (β = 0.22 (95% confidence interval (CI); 0.03, 0.41)), greater risk of femoral BMLs (RR = 1.46 (1.12, 1.90)) and worse tibial cartilage defects score (RR = 1.70 (1.16, 2.47), and smaller IPFP area (β = -0.27 (-0.47, -0.06) cm2), after adjustment of confounders. Longitudinally, presence of baseline PTE abnormalities was associated with a deleterious increase in tibial BML size (RR = 1.52 (1.12, 2.05)) over 10.7 years but not symptoms, other structural changes, or TKR.

Conclusion: PTE abnormalities are common in older adults. Presence of cross-sectional but not longitudinal associations suggests they are commonly co-exist with other knee structural abnormalities but may not play a major role in symptom development or structural change, excepting tibial BMLs.

Item Details

Item Type:Refereed Article
Keywords:patellar tendon enthesis, enthesis abnormalities, enthesopathy, osteoarthritis, MRI, knee
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Mattap, SM (Miss Siti Mattap)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:Wills, K (Dr Karen Wills)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Munugoda, I (Mr Ishanka Munugoda)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Laslett, LL (Dr Laura Laslett)
ID Code:130068
Year Published:2018
Funding Support:National Health and Medical Research Council (1070586)
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-01-09
Last Modified:2019-03-18
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