Cuellar, WA and Blizzard, L and Hides, JA and Callisaya, ML and Jones, G and Cicuttini, F and Wluka, AE and Ding, C and Winzenberg, TM, Vitamin D supplements for trunk muscle morphology in older adults: secondary analysis of a randomized controlled trial, Journal of Cachexia, Sarcopenia and Muscle pp. 1-11. ISSN 2190-5991 (2018) [Refereed Article]
Methods: This was a secondary analysis of a randomized, placebo-controlled, and double-blind clinical trial conducted between June 2010 and December 2013 in Tasmania, Australia. The clinical trial was registered with the Australian New Zealand clinical trial registration agency, ClinicalTrials.gov identifier: NCT01176344; Australian New Zealand Clinical Trials Registry: ACTRN 12610000495022. Participants were aged 50-79 years with ongoing symptoms of knee osteoarthritis and with low serum [25(OH) D] (12.5 to 60 nmol/L, 5.2 to 24 ng/mL). Participants were randomly assigned to either monthly 50 000 IU oral vitamin D3 (n = 104) or an identical placebo (n = 113) for 24 months as per clinical trial protocol. The primary outcomes in this pre-specified secondary analysis were between-group differences in change in size of rectus abdominis, transversus abdominis, internal oblique, external oblique, and lumbar multifidus muscles and function (assessed by change in thickness on contraction) of these muscles (excepting rectus abdominis) from baseline to 12 months. Muscle size was assessed using ultrasound imaging.
Results: Of 217 participants (mean age 63 years, 48% women), 186 (85.7%) completed the study. There were no significant between-group differences in change in size or function of the abdominal or multifidus muscles after 12 months of vitamin D supplementation.
Conclusions: A monthly dose of 50 000 IU of vitamin D3 alone for 12 months does not affect the size or ability to contract trunk muscles of independent community-dwelling older adults with symptomatic knee osteoarthritis and low serum 25(OH) D levels regardless of body mass index status or degree of vitamin D deficiency. An effect of vitamin D supplementation on other aspects of trunk muscle function such as strength, power, or physical function cannot be ruled out.
|Item Type:||Refereed Article|
|Keywords:||muscle size and function, older adults, postural trunk muscles, randomized controlled trial, ultrasound imaging; vitamin D supplementation|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Cuellar, WA (Mr William Cuellar)|
|UTAS Author:||Blizzard, L (Professor Leigh Blizzard)|
|UTAS Author:||Callisaya, ML (Dr Michele Callisaya)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|UTAS Author:||Winzenberg, TM (Professor Tania Winzenberg)|
|Deposited By:||Menzies Institute for Medical Research|
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