Zhu, Z and Ding, C and Han, W and Zheng, S and Winzenberg, T and Cicuttini, F and Jones, G, MRI-detected osteophytes of the knee: natural history and structural correlates of change, Arthritis Research & Therapy, 20, (1) Article 237. ISSN 1478-6362 (2018) [Refereed Article]
Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Methods: Randomly selected older adults (n = 837, mean age 63 years) had MRI at baseline and 413 of them had MRI 2.6 years later to measure MRI-detected OP, cartilage defects, cartilage volume, bone marrow lesions (BMLs), meniscal extrusion, infrapatellar fat pad (IPFP) quality score/maximum area and effusion-synovitis.
Results: Over 2.6 years, average MRI-detected OP score increased significantly in all compartments. The total MRI-detected OP score remained stable in 53% of participants, worsened (≥ 1-point increase) in 46% and decreased in 1%. Baseline cartilage defects (RR, 1.25-1.35), BMLs (RR, 1.16-1.17), meniscal extrusion (RR, 1.22-1.33) and IPFP quality score (RR, 1.08-1.20) site-specifically and independently predicted an increase in MRI-detected OP (p values all ≤ 0.05), after adjustment for covariates. Presence of IPFP abnormality was significantly associated with increased MRI-detected OPs but became non-significant after adjustment for other structural abnormalities. Total (RR, 1.27) and suprapatellar pouch effusion-synovitis (RR, 1.22) were both associated with increased MRI-detected OPs in the lateral compartment only (both p < 0.04).
Conclusion: Knee MRI-detected OPs are common in older adults and are likely to progress. The association between baseline structural abnormalities and worsening MRI-detected OPs suggest MRI-detected OP could be a consequence of multiple knee structural abnormalities.
|Item Type:||Refereed Article|
|Keywords:||osteoarthritis, magnetic resonance imaging, steophyte, natural history|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Zhu, Z (Mr Zhaohua Zhu)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|UTAS Author:||Han, W (Dr Weiyu Han)|
|UTAS Author:||Zheng, S (Miss Shuang Zheng)|
|UTAS Author:||Winzenberg, T (Professor Tania Winzenberg)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||14 View Download Statistics|
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