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Longitudinal associations of the healthy lifestyle index score with quality of life in people with multiple sclerosis: A prospective cohort study


Leong, TI and Weiland, TJ and Jelinek, GA and Simpson, S and Brown, CR and Neate, SL and Taylor, KL and O'Kearney, E and Milanzi, E and De Livera, AM, Longitudinal associations of the healthy lifestyle index score with quality of life in people with multiple sclerosis: A prospective cohort study, Frontiers in Neurology, 9 Article 874. ISSN 1664-2295 (2018) [Refereed Article]


Copyright Statement

Copyright 2018 Leong, Weiland, Jelinek, Simpson, Brown, Neate, Taylor, O'Kearney, Milanzi and De Livera. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fneur.2018.00874


Objective: To explore the association between combined lifestyle risk factors with quality of life in people with multiple sclerosis (MS) over 2.5 years.

Methods: People with MS were recruited to participate in a comprehensive online survey regarding their demographic and clinical characteristics, health-related quality of life (HRQOL), and lifestyle behaviors including physical activity, alcohol consumption, cigarette smoking, body mass index, and dietary habits measured at baseline and 2.5-year follow-up. A combined healthy lifestyle index score (HLIS) was constructed by assigning scores of 0-4 to each of the lifestyle risk factors, for which higher values indicate healthier lifestyle behavior. Multivariable linear regression modeling was used to assess whether the HLIS at baseline was associated with the physical and mental HRQOL over the study period in this sample of people with MS.

Results: Of 2,466 participants with confirmed MS, 1,401 (57%) completed the follow-up. Multivariable linear regression analyses demonstrated that every 5-point increase (of a possible total of 20) in the baseline HLIS was associated with 1.7 (95% CI: 0.2-3.2) and 2.5 (95% CI: 1.0-4.0) higher scores in the change in physical and mental HRQOL components from baseline to follow-up respectively.

Conclusion: Findings suggest the importance of healthy lifestyle behavior in quality of life in MS. A healthy lifestyle program focusing on these behaviors has the potential to positively influence health-related quality of life for people with MS.

Item Details

Item Type:Refereed Article
Keywords:QOL, health outcomes, lifestyle, multiple sclerosis, quality of life, risk factors
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Simpson, S (Dr Steve Simpson JR)
ID Code:129836
Year Published:2018
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-12-19
Last Modified:2019-01-21
Downloads:115 View Download Statistics

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