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Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology


Chong, WC and Shastri, MD and Eri, R, Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology, International Journal of Molecular Sciences, 18 (4) Article 771. ISSN 1661-6596 (2017) [Substantial Review]


Copyright Statement

2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3390/ijms18040771


The endoplasmic reticulum (ER) is a complex protein folding and trafficking organelle. Alteration and discrepancy in the endoplasmic reticulum environment can affect the protein folding process and hence, can result in the production of misfolded proteins. The accumulation of misfolded proteins causes cellular damage and elicits endoplasmic reticulum stress. Under such stress conditions, cells exhibit reduced functional synthesis, and will undergo apoptosis if the stress is prolonged. To resolve the ER stress, cells trigger an intrinsic mechanism called an unfolded protein response (UPR). UPR is an adaptive signaling process that triggers multiple pathways through the endoplasmic reticulum transmembrane transducers, to reduce and remove misfolded proteins and improve the protein folding mechanism, in order to improve and maintain endoplasmic reticulum homeostasis. An increasing number of studies support the view that oxidative stress has a strong connection with ER stress. During the protein folding process, reactive oxygen species are produced as by-products, leading to impaired reduction-oxidation (redox) balance conferring oxidative stress. As the protein folding process is dependent on redox homeostasis, the oxidative stress can disrupt the protein folding mechanism and enhance the production of misfolded proteins, causing further ER stress. It is proposed that endoplasmic reticulum stress and oxidative stress together play significant roles in the pathophysiology of bowel diseases.

Item Details

Item Type:Substantial Review
Keywords:gastrointestinal, ER stress, colitis, endoplasmic reticulum stress, unfolded protein response, oxidative stress, antioxidant mechanisms, misfolded protein, inflammatory bowel disease
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetic immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Chong, WC (Mr Wai Chong)
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:129779
Year Published:2017
Web of Science® Times Cited:118
Deposited By:Health Sciences
Deposited On:2018-12-18
Last Modified:2019-06-18
Downloads:76 View Download Statistics

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