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The third wave: Intermediate filaments in the maturing nervous system
journal contribution
posted on 2023-05-22, 23:52 authored by Matthew KirkcaldieMatthew Kirkcaldie, Samuel DwyerSamuel DwyerIntermediate filaments are critical for the extreme structural specialisations of neurons, providing integrity in dynamic environments and efficient communication along axons a metre or more in length. As neurons mature, an initial expression of nestin and vimentin gives way to the neurofilament triplet proteins and α-internexin, substituted by peripherin in axons outside the CNS, which physically consolidate axons as they elongate and find their targets. Once connection is established, these proteins are transported, assembled, stabilised and modified, structurally transforming axons and dendrites as they acquire their full function. The interaction between these neurons and myelinating glial cells optimises the structure of axons for peak functional efficiency, a property retained across their lifespan. This finely calibrated structural regulation allows the nervous system to maintain timing precision and efficient control across large distances throughout somatic growth and, in maturity, as a plasticity mechanism allowing functional adaptation.
Funding
Brain Foundation
History
Publication title
Molecular and Cellular NeurosciencesVolume
84Pagination
68-76ISSN
1044-7431Department/School
Wicking Dementia Research Education CentrePublisher
Academic Press Inc Elsevier SciencePlace of publication
525 B St, Ste 1900, San Diego, USA, Ca, 92101-4495Rights statement
Copyright 2017 Elsevier Ltd.Repository Status
- Restricted