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The third wave: Intermediate filaments in the maturing nervous system
Citation
Kirkcaldie, MTK and Dwyer, ST, The third wave: Intermediate filaments in the maturing nervous system, Molecular and Cellular Neurosciences, 84 pp. 68-76. ISSN 1044-7431 (2017) [Substantial Review]
Copyright Statement
Copyright 2017 Elsevier Ltd.
DOI: doi:10.1016/j.mcn.2017.05.010
Abstract
Intermediate filaments are critical for the extreme structural specialisations of neurons, providing integrity in dynamic environments and efficient communication along axons a metre or more in length. As neurons mature, an initial expression of nestin and vimentin gives way to the neurofilament triplet proteins and α-internexin, substituted by peripherin in axons outside the CNS, which physically consolidate axons as they elongate and find their targets. Once connection is established, these proteins are transported, assembled, stabilised and modified, structurally transforming axons and dendrites as they acquire their full function. The interaction between these neurons and myelinating glial cells optimises the structure of axons for peak functional efficiency, a property retained across their lifespan. This finely calibrated structural regulation allows the nervous system to maintain timing precision and efficient control across large distances throughout somatic growth and, in maturity, as a plasticity mechanism allowing functional adaptation.
Item Details
Item Type: | Substantial Review |
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Keywords: | neurofilaments, cytoskeleton, myelin, development, intermediate filaments, plasticity |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Kirkcaldie, MTK (Dr Matthew Kirkcaldie) |
UTAS Author: | Dwyer, ST (Mr Samuel Dwyer) |
ID Code: | 129774 |
Year Published: | 2017 |
Web of Science® Times Cited: | 19 |
Deposited By: | Medicine |
Deposited On: | 2018-12-18 |
Last Modified: | 2018-12-18 |
Downloads: | 0 |
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