eCite Digital Repository

Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox


Eapen, MS and Myers, S and Walters, EH and Sohal, SS, Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox, Expert Review of Respiratory Medicine, 11, (10) pp. 827-839. ISSN 1747-6348 (2017) [Substantial Review]

Copyright Statement

2017 Informa UK Limited

DOI: doi:10.1080/17476348.2017.1360769


Chronic obstructive pulmonary disease (COPD) is primarily an airway condition, which mainly affects cigarette smokers and presents with shortness of breath that is progressive and poorly reversible. In COPD research, there has been a long held belief that airway disease progression is due to inflammation. Although this may be true in the airway lumen with innate immunity activated by the effect of smoke or secondary to infection, the accurate picture of inflammatory cells in the airway wall, where the pathophysiological COPD remodeling occurs, is uncertain and debatable. Areas covered: The current review provides a comprehensive literature survey of the changes in the main inflammatory cells in human COPD patients and focuses on contrarian views that affect the prevailing dogma on inflammation. The review also delves into the role of oxidative stress and inflammasomes in modulating the immune response in COPD. Further, the effects of inflammation in affecting the epithelium, fibroblasts, and airway remodeling are discussed. Expert commentary: Inflammation as a driving force for airway wall damage and remodelling in early COPD is at the very least 'oversimplified' and is likely to be misleading. This has serious implications for rational thinking about the illness, including pathogenesis and designing therapy.

Item Details

Item Type:Substantial Review
Keywords:COPD, ICS, lung cancer, EMT, chronic obstructive pulmonary disease, airway cellularity, airway inflammation, inflammasome, airway remodeling, reactive oxygen species, epithelial-mesenchymal transition
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Eapen, MS (Mr Mathew Eapen)
UTAS Author:Myers, S (Dr Stephen Myers)
UTAS Author:Walters, EH (Professor Haydn Walters)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:129762
Year Published:2017
Web of Science® Times Cited:1
Deposited By:Health Sciences
Deposited On:2018-12-18
Last Modified:2018-12-18

Repository Staff Only: item control page