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The role of epithelial-mesenchymal transition in chronic obstructive pulmonary disease


Courtney, J-M and Spafford, PL, The role of epithelial-mesenchymal transition in chronic obstructive pulmonary disease, Cells, Tissues, Organs, 203, (2) pp. 99-104. ISSN 1422-6405 (2017) [Review Several Works]

Copyright Statement

2017 S. Karger AG, Basel

DOI: doi:10.1159/000450919


Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, and there is currently no treatment that can halt the progression of the disease. Over the last decade there has been increasing interest in the idea that epithelial-mesenchymal transition (EMT) may be active in COPD. Here we review the evidence for EMT in COPD as well as the current progress being made on understanding the drivers and mechanisms involved. Finally, we discuss the potential benefits that understanding EMT may bring to the field of chronic respiratory disease.

Item Details

Item Type:Review Several Works
Keywords:epithelial-mesenchymal transition, chronic obstructive pulmonary disease, cigarette smoke, nicotine, airway epithelium
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Courtney, J-M (Dr Jo-Maree Courtney)
UTAS Author:Spafford, PL (Miss Patricia Spafford)
ID Code:129754
Year Published:2017
Web of Science® Times Cited:8
Deposited By:Medicine
Deposited On:2018-12-18
Last Modified:2018-12-18

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