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Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review

Citation

Tan, J and Iyer, KK and Tang, AD and Jamil, A and Martins, RN and Sohrabi, HR and Nitsche, MA and Hinder, M and Fujiyama, H, Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review, Neuroimage, 185 pp. 490-512. ISSN 1053-8119 (2019) [Substantial Review]


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DOI: doi:10.1016/j.neuroimage.2018.10.044

Abstract

Response inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.

Item Details

Item Type:Substantial Review
Keywords:brain stimulation, response inhibition, brain connectivity
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Developmental Psychology and Ageing
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in Psychology and Cognitive Sciences
UTAS Author:Hinder, M (Dr Mark Hinder)
ID Code:129743
Year Published:2019
Funding Support:Australian Research Council (FT150100406)
Web of Science® Times Cited:2
Deposited By:Psychology
Deposited On:2018-12-17
Last Modified:2018-12-17
Downloads:0

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