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Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review
journal contribution
posted on 2023-05-22, 23:50 authored by Tan, J, Iyer, KK, Tang, AD, Jamil, A, Martins, RN, Sohrabi, HR, Nitsche, MA, Mark HinderMark Hinder, Fujiyama, HResponse inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.
Funding
Australian Research Council
History
Publication title
NeuroimageVolume
185Pagination
490-512ISSN
1053-8119Department/School
School of Psychological SciencesPublisher
Academic Press Inc Elsevier SciencePlace of publication
525 B St, Ste 1900, San Diego, USA, Ca, 92101-4495Repository Status
- Restricted