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Compression socks and the effects on coagulation and fibrinolytic activation during marathon running

Citation

Zadow, EK and Adams, MJ and Wu, SSX and Kitic, CM and Singh, I and Kundur, A and Bost, N and Johnston, ANB and Crilly, J and Bulmer, AC and Halson, SL and Fell, JW, Compression socks and the effects on coagulation and fibrinolytic activation during marathon running, European Journal of Applied Physiology, 118, (10) pp. 2171-2177. ISSN 1439-6319 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Springer-Verlag GmbH Germany, part of Springer Nature

DOI: doi:10.1007/s00421-018-3929-5

Abstract

Purpose: Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear.

Objectives: To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon.

Methods: Sixty-seven participants [43 males (mean±SD: age: 46.7±10.3 year) and 24 females (age: 40.0±11.0 year)] were allocated into a compression (SOCK, n=34) or control (CONTROL, n=33) group. Venous blood samples were obtained 24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and D-Dimer.

Results: Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median (range) SOCK: +9.02 (−0.34 to 60.7) ng/mL, CONTROL: +25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: +1.19 (−7.47 to 9.11) pg/mL, CONTROL: +3.47 (−5.01 to 38.56) pg/mL] in all runners. No significant post-exercise changes were observed for TAT and TFPI.

Conclusions: While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression may reduce exercise-associated haemostatic activation when completing prolonged exercise.

Item Details

Item Type:Refereed Article
Keywords:compression, D-dimer, Tissue factor, Tissue factor pathway inhibitor, thrombin-anti-thrombin complexes
Research Division:Medical and Health Sciences
Research Group:Human Movement and Sports Science
Research Field:Exercise Physiology
Objective Division:Health
Objective Group:Specific Population Health (excl. Indigenous Health)
Objective Field:Specific Population Health (excl. Indigenous Health) not elsewhere classified
UTAS Author:Zadow, EK (Ms Emma Zadow)
UTAS Author:Adams, MJ (Dr Murray Adams)
UTAS Author:Wu, SSX (Dr Sam Wu)
UTAS Author:Kitic, CM (Dr Cecilia Kitic)
UTAS Author:Fell, JW (Associate Professor James Fell)
ID Code:129738
Year Published:2018
Web of Science® Times Cited:3
Deposited By:Health Sciences
Deposited On:2018-12-17
Last Modified:2019-03-25
Downloads:0

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