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How do cells of the oligodendrocyte lineage affect neuronal circuits to influence motor function, memory and mood?


Pepper, RE and Pitman, KA and Cullen, CL and Young, KM, How do cells of the oligodendrocyte lineage affect neuronal circuits to influence motor function, memory and mood?, Frontiers in Cellular Neuroscience, 12 Article 399. ISSN 1662-5102 (2018) [Refereed Article]


Copyright Statement

Copyright 2018 Pepper, Pitman, Cullen and Young. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fncel.2018.00399


Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system (CNS) that can rapidly respond to changes within their environment by modulating their proliferation, motility and differentiation. OPCs differentiate into myelinating oligodendrocytes throughout life, and both cell types have been implicated in maintaining and modulating neuronal function to affect motor performance, cognition and emotional state. However, questions remain about the mechanisms employed by OPCs and oligodendrocytes to regulate circuit function, including whether OPCs can only influence circuits through their generation of new oligodendrocytes, or can play other regulatory roles within the CNS. In this review, we detail the molecular and cellular mechanisms that allow OPCs, newborn oligodendrocytes and pre-existing oligodendrocytes to regulate circuit function and ultimately influence behavioral outcomes.

Item Details

Item Type:Refereed Article
Keywords:NG2 glia, myelin, oligodendrocyte, anxiety, motor function, depression, learning, neuronal activity
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Pepper, RE (Miss Renee Pepper)
UTAS Author:Pitman, KA (Dr Kimberley Pitman)
UTAS Author:Cullen, CL (Dr Carlie Cullen)
UTAS Author:Young, KM (Professor Kaylene Young)
ID Code:129370
Year Published:2018
Web of Science® Times Cited:35
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-11-27
Last Modified:2022-08-23
Downloads:146 View Download Statistics

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