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Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities

Citation

Eapen, MS and Hansbro, PM and Larssona-Callerfelt, AK and Jolly, MK and Myers, S and Sharma, P and Jones, B and Rahman, MA and Markos, J and Chia, C and Larby, J and Haug, G and Hardikar, A and Weber, HC and Mabeza, G and Cavalheri, V and Khor, YH and McDonald, CF and Sohal, SS, Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities, Drugs, 78, (16) pp. 1717-1740. ISSN 0012-6667 (2018) [Refereed Article]


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Copyright Springer Nature Switzerland AG 2018

DOI: doi:10.1007/s40265-018-1001-8

Abstract

Chronic obstructive pulmonary disease (COPD) and lung cancer are major lung diseases affecting millions worldwide. Both diseases have links to cigarette smoking and exert a considerable societal burden. People suffering from COPD are at higher risk of developing lung cancer than those without, and are more susceptible to poor outcomes after diagnosis and treatment. Lung cancer and COPD are closely associated, possibly sharing common traits such as an underlying genetic predisposition, epithelial and endothelial cell plasticity, dysfunctional inflammatory mechanisms including the deposition of excessive extracellular matrix, angiogenesis, susceptibility to DNA damage and cellular mutagenesis. In fact, COPD could be the driving factor for lung cancer, providing a conducive environment that propagates its evolution. In the early stages of smoking, body defences provide a combative immune/oxidative response and DNA repair mechanisms are likely to subdue these changes to a certain extent; however, in patients with COPD with lung cancer the consequences could be devastating, potentially contributing to slower postoperative recovery after lung resection and increased resistance to radiotherapy and chemotherapy. Vital to the development of new-targeted therapies is an in-depth understanding of various molecular mechanisms that are associated with both pathologies. In this comprehensive review, we provide a detailed overview of possible underlying factors that link COPD and lung cancer, and current therapeutic advances from both human and preclinical animal models that can effectively mitigate this unholy relationship.

Item Details

Item Type:Refereed Article
Keywords:IPF, asthma, ACOS, ACO, COPD, epithelium, fibrosis, EMT, cancer, ICS, inflammation
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Eapen, MS (Mr Mathew Eapen)
UTAS Author:Myers, S (Dr Stephen Myers)
UTAS Author:Markos, J (Dr Jim Markos)
UTAS Author:Larby, J (Dr Josie Larby)
UTAS Author:Haug, G (Dr Greg Haug)
UTAS Author:Hardikar, A (Dr Ashutosh Hardikar)
UTAS Author:Weber, HC (Dr Heinrich Weber)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:129357
Year Published:2018
Web of Science® Times Cited:1
Deposited By:Health Sciences
Deposited On:2018-11-26
Last Modified:2019-03-20
Downloads:0

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