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Non-invasive measurement of reservoir pressure parameters from brachial-cuff blood pressure waveforms

Citation

Peng, X and Schultz, MG and Picone, DS and Dwyer, N and Black, JA and Roberts-Thomson, P and Sharman, JE, Non-invasive measurement of reservoir pressure parameters from brachial-cuff blood pressure waveforms, Journal of Clinical Hypertension, 20, (12) pp. 1703-1711. ISSN 1524-6175 (2018) [Refereed Article]


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Copyright Statement

This is the pre-peer reviewed version of the following article: Peng, X and Schultz, MG and Picone, DS and Dwyer, N and Black, JA and Roberts-Thomson, P and Sharman, JE, Non-invasive measurement of reservoir pressure parameters from brachial-cuff blood pressure waveforms, Journal of Clinical Hypertension, 20, (12) pp. 1703-1711 which has been published in final form at http://dx.doi.org/10.1111/jch.13411. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

DOI: doi:10.1111/jch.13411

Abstract

Reservoir pressure parameters [eg, reservoir pressure (RP) and excess pressure (XSP)] are biomarkers derived from blood pressure (BP) waveforms that have been shown to predict cardiovascular events independent of conventional cardiovascular risk markers. However, whether RP and XSP can be derived non-invasively from operator-independent cuff device measured brachial or central BP waveforms has never been examined. This study sought to achieve this by comparison of cuff reservoir pressure parameters with intra-aortic reservoir pressure parameters. 162 participants (aged 61 ± 10 years, 72% male) undergoing coronary angiography had the simultaneous measurement of cuff BP waveforms (via SphygmoCor XCEL, AtCor Medical) and intra-aortic BP waveforms (via fluid-filled catheter). RP and XSP derived from cuff acquired brachial and central BP waveforms were compared with intra-aortic measures. Concordance between brachial-cuff and intra-aortic measurement was moderate-to-good for RP peak (36 ± 11 vs 48 ± 14 mm Hg, P < 0.001; ICC 0.77, 95% CI: 0.71-0.82), and poor-to-moderate for XSP peak (28 ± 10 vs 24 ± 9 mm Hg, P < 0.001; ICC 0.49, 95% CI: 0.35-0.60). Concordance between central-cuff and intra-aortic measurement was moderate-to-good for RP peak (35 ± 9 vs 46 ± 14 mm Hg, P < 0.001; ICC 0.77, 95% CI: 0.70-0.82), but poor for XSP peak (12 ± 3 vs 24 ± 9 mm Hg, P < 0.001; ICC 0.12, 95% CI: -0.13 to 0.31). In conclusion, both brachial-cuff and central-cuff methods can reasonably estimate intra-aortic RP, whereas XSP can only be acceptably derived from brachial-cuff BP waveforms. This should enable widespread application to determine the clinical significance, but there is significant room for refinement of the method.

Item Details

Item Type:Refereed Article
Keywords:arterial blood pressure, hemodynamics, non-invasive, oscillometry, reservoir
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Peng, X (Miss Xiaoqing Peng)
UTAS Author:Schultz, MG (Dr Martin Schultz)
UTAS Author:Picone, DS (Mr Dean Picone)
UTAS Author:Dwyer, N (Dr Nathan Dwyer)
UTAS Author:Black, JA (Dr Andrew Black)
UTAS Author:Roberts-Thomson, P (Dr Philip Roberts-Thomson)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:129303
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-11-22
Last Modified:2018-12-12
Downloads:31 View Download Statistics

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