Peterson, GM and Thomas, J and Yee, KC and Kosari, S and Naunton, M and Olesen, IH, Monoclonal antibody therapy in cancer: when two is better (and considerably more expensive) than one, Journal of Clinical Pharmacy and Therapeutics, 43, (6) pp. 925-930. ISSN 0269-4727 (2018) [Contribution to Refereed Journal]
© 2018 John Wiley & Sons Ltd
What is known and objective: It is 20 years since the US Food and Drug Administration approved the first successful monoclonal anticancer antibody, trastuzumab. The therapeutic utility of monoclonal antibodies in cancer is often limited by partial clinical responses and the development of tumour resistance. An expanding strategy, to be reviewed here, to overcome the limited response and resistance to monotherapy utilizes concurrent treatment with two synergistic monoclonal antibodies.
Comment: Key examples include two monoclonal antibodies, each engaging a distinct site of human epidermal growth factor receptor 2 (HER2), in the treatment of breast cancer and a combination of antibodies to two distinct T-cell antigens for the treatment of melanoma. Here, we provide an overview of the rationale and evidence for using selected monoclonal antibodies in combination for treating some cancers, along with potential hazards, especially autoimmune-related toxicities.
What is new and conclusion: Thorough research, the development of panels of biomarkers and individualization of therapy will be necessary to optimize the use of these combinations and minimize the substantial risk of overstimulating the immune system.
|Item Type:||Contribution to Refereed Journal|
|Keywords:||cancer, combination, immune checkpoint, monoclonal antibody, toxicity|
|Research Division:||Medical and Health Sciences|
|Research Group:||Pharmacology and Pharmaceutical Sciences|
|Research Field:||Clinical Pharmacology and Therapeutics|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cancer and Related Disorders|
|UTAS Author:||Peterson, GM (Professor Gregory Peterson)|
|Web of Science® Times Cited:||3|
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