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Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals


Doupe, DP and Marshall, OJ and Dayton, H and Brand, AH and Perrimon, N, Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals, Proceedings of the National Academy of Sciences of The United States of America pp. 1-6. ISSN 0027-8424 (2018) [Refereed Article]


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Copyright 2018 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1073/pnas.1719169115


Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain unidentified. Here, we use gene-expression profiling by targeted DamID to identify the stem/progenitor-specific transcription and signaling factors in the Drosophila midgut. Many signaling pathway components, including ligands of most major pathways, exhibit stem/progenitor-specific expression and have regulatory regions bound by both intrinsic and extrinsic transcription factors. In addition to previously identified stem/progenitor-derived ligands, we show that both the insulin-like factor Ilp6 and TNF ligand eiger are specifically expressed in the stem/progenitors and regulate normal tissue homeostasis. We propose that intestinal stem cells not only integrate multiple signals but also contribute to and regulate the homeostatic signaling microenvironmental niche through the expression of autocrine and paracrine factors.

Item Details

Item Type:Refereed Article
Keywords:epithelial homeostasis, insulin, microenvironment, niche, stem cells
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biotechnology
Research Field:Regenerative medicine (incl. stem cells)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Marshall, OJ (Dr Owen Marshall)
ID Code:129206
Year Published:2018
Web of Science® Times Cited:31
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-11-15
Last Modified:2018-12-14
Downloads:130 View Download Statistics

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