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Seven-Membered Rings


Meyer, AG and Bissember, AC and Hyland, CJT and Williams, CC and Szabo, M and Abel, S-AG and Bird, MJ and Hyland, IK and Pham, H, Seven-Membered Rings, Progress in Heterocyclic Chemistry, Elsevier Science Bv, GW Gribble & JA Joule (ed), Amsterdam, Netherlands, pp. 493-550. ISBN 978-0-08-102788-2 (2018) [Research Book Chapter]

Copyright Statement

Copyright 2018 Elsevier Ltd.

DOI: doi:10.1016/B978-0-08-102788-2.00016-7


New synthetic methods continue to be developed to construct seven-membered heterocyclic compounds containing one, two, or three of the heteroatoms N, O, or S. The focus of much of the literature has been on aromatic systems containing at least 1 N atom and has often been driven by a desire to prepare these heterocycles in a stereocontrolled fashion, the search for new bioactives, and the synthesis of natural products. Prominent synthetic methods include transition metal-catalyzed, cycloaddition/annulation, cascade-type, and CeH functionalization processes. Review articles on the synthesis of seven-membered nitrogen heterocycles through the Ugi multicomponent reaction (17CHE382), synthetic approaches, and biological activities of benzodiazepines (17MOC453), the isolation, structure determination, medicinal properties, and total synthesis of marine natural products containing an oxepanyl ring (17MAD361), the synthesis and medicinal importance of benzoxepines (17LDD1086), methods for the synthesis of 1,2,3-, 1,2,4-, 1,2,5-, and 1,3,5-triazepines (17JCCS1023), and the isolation, biosynthesis, and biological activity of natural products that contain a sevenmembered ring with three or more heteroatoms (17JNP3060), as well as indole-fused azepines and analogs as anticancer lead molecules (17EJM244) have been published.

Item Details

Item Type:Research Book Chapter
Keywords:heterocycles, organic synthesis
Research Division:Chemical Sciences
Research Group:Organic chemistry
Research Field:Organic chemical synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Bissember, AC (Associate Professor Alex Bissember)
UTAS Author:Abel, S-AG (Dr Steve Abel)
UTAS Author:Hyland, IK (Ms Isabel Hyland)
ID Code:129177
Year Published:2018
Deposited By:Chemistry
Deposited On:2018-11-13
Last Modified:2018-12-04

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