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A randomized controlled trial of adherence to a 24-month home-based physical activity program and the health benefits for older adults at risk of Alzheimer’s disease: The AIBL active-study


Cox, KL and Cyarto, EV and Ellis, KA and Ames, D and Desmond, P and Phal, P and Sharman, MJ and Szoeke, C and Rowe, CC and Masters, CL and You, E and Burrows, S and Lai, MMY and Lautenschlager, NT, A randomized controlled trial of adherence to a 24-month home-based physical activity program and the health benefits for older adults at risk of Alzheimer's disease: The AIBL active-study, Journal of Alzheimer's Disease pp. 1-19. ISSN 1387-2877 (2018) [Refereed Article]

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© 2018 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC 4.0)

DOI: doi:10.3233/JAD-180521


Background: Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcomes in older adults, but most have been relatively short in duration (<1 year) with a few having specifically targeting individuals at risk of developing Alzheimer’s disease.

Objective: To examine adherence and physical health outcomes in a 24-month home-based PA intervention in older adults at risk of Alzheimer’s disease.

Methods: Participants 60 years and older with mild cognitive impairment (MCI) or subjective memory complaints (SMC) with at least 1 cerebrovascular risk factor recruited from The Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL) were randomized to a PA or control group (n = 106). The control group continued with their usual lifestyle. The PA group received a 24-month home-based program with a target of 150 minutes/week of moderate PA and a behavioral intervention. Retention (participants remaining) and PA adherence (PA group only, percent PA completed to the PA prescribed) were determined at 6, 12, 18, and 24 months. Assessments at baseline, 6, 12, and 24 months included, PA; fitness; body composition and fat distribution. Key outcome measures were PA adherence and PA.

Results: The 24-month retention rate (97.2%) and the median PA adherence 91.67% (Q1–Q3, 81.96, 100.00) were excellent. In the long-term the intervention group achieved significantly better improvements in PA levels, leg strength, fat mass and fat distribution compared to the control.

Conclusion: This study demonstrates that in this target group, long-term PA adherence is achievable and has physical health benefits.

Item Details

Item Type:Refereed Article
Keywords:cerebrovascular disease, mild cognitive impairment, physical activity, subjective memory complaints
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, MJ (Dr Matt Sharman)
ID Code:129137
Year Published:2018
Funding Support:National Health and Medical Research Council (APP1005942)
Web of Science® Times Cited:12
Deposited By:Health Sciences
Deposited On:2018-11-12
Last Modified:2022-08-23
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