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Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults

Citation

Meng, T and Venn, A and Eckstein, F and Wirth, W and Cicuttini, F and March, L and Dwyer, T and Cross, M and Laslett, LL and Jones, G and Ding, C and Antony, B, Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults, International Journal of Obesity pp. 1-11. ISSN 0307-0565 (2018) [Refereed Article]

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Copyright Statement

Springer Nature Limited 2018

DOI: doi:10.1038/s41366-018-0234-7

Abstract

Objective: To describe the associations of childhood and adulthood adiposity measures with knee cartilage thickness, volume and bone area in young adults.

Methods: Childhood and adulthood adiposity measures (weight, height, waist circumference and hip circumference) of 186 participants were collected in 1985 (aged 715 years) and during 20042006 (aged 2636 years). Knee magnetic resonance imaging was conducted during 20082010 (aged 3141 years) and cartilage thickness, volume and bone area were measured using a quantitative approach (Chondrometrics, Germany). Linear regressions were used to examine the above associations.

Results: The prevalence of overweight was 7.6% in childhood and 42.1% in adulthood. Childhood weight (β = - 5.57 mm2/kg) and body mass index (BMI) (β = - 11.55 mm2/kg/m2) were negatively associated with adult patellar bone area, whereas adult weight was positively associated with bone area in medial femorotibial compartment (MFTC) (β = 3.37 mm2/kg) and lateral femorotibial compartment (LFTC) (β = 2.08 mm2/kg). Adult waist-hip ratio (WHR) was negatively associated with cartilage thickness (MFTC: β = - 0.011; LFTC: β = - 0.012 mm/0.01 unit), volume (Patella: β = - 20.97; LFTC: β = - 21.71 mm3/0.01 unit) and bone area (Patella: β = - 4.39 mm2/0.01 unit). The change in WHR z-scores from childhood to adulthood was negatively associated with cartilage thickness (MFTC: β = - 0.056 mm), volume (patella: - 89.95; LFTC: - 93.98 mm3), and bone area (patella: - 20.74 mm2). All p-values < 0.05.

Conclusions: Childhood weight and BMI were negatively but adult weight was positively associated with adult bone area. Adult WHR and the change in WHR from childhood to adulthood were negatively associated with cartilage thickness, volume, and bone area. These suggest early-life adiposity measures may affect knee structures in young adults.

Item Details

Item Type:Refereed Article
Keywords:obesity, adiposity, cartilage morphology, cartilage thickness, cartilage volume, bone area, young adults
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Meng, T (Mr Tao Meng)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Laslett, LL (Dr Laura Laslett)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
ID Code:129016
Year Published:2018
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-11-01
Last Modified:2019-01-18
Downloads:63 View Download Statistics

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