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Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults
Citation
Meng, T and Venn, A and Eckstein, F and Wirth, W and Cicuttini, F and March, L and Dwyer, T and Cross, M and Laslett, LL and Jones, G and Ding, C and Antony, B, Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults, International Journal of Obesity pp. 1-11. ISSN 0307-0565 (2018) [Refereed Article]
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Copyright Statement
© Springer Nature Limited 2018
DOI: doi:10.1038/s41366-018-0234-7
Abstract
Methods: Childhood and adulthood adiposity measures (weight, height, waist circumference and hip circumference) of 186 participants were collected in 1985 (aged 7–15 years) and during 2004–2006 (aged 26–36 years). Knee magnetic resonance imaging was conducted during 2008–2010 (aged 31–41 years) and cartilage thickness, volume and bone area were measured using a quantitative approach (Chondrometrics, Germany). Linear regressions were used to examine the above associations.
Results: The prevalence of overweight was 7.6% in childhood and 42.1% in adulthood. Childhood weight (β = - 5.57 mm2/kg) and body mass index (BMI) (β = - 11.55 mm2/kg/m2) were negatively associated with adult patellar bone area, whereas adult weight was positively associated with bone area in medial femorotibial compartment (MFTC) (β = 3.37 mm2/kg) and lateral femorotibial compartment (LFTC) (β = 2.08 mm2/kg). Adult waist-hip ratio (WHR) was negatively associated with cartilage thickness (MFTC: β = - 0.011; LFTC: β = - 0.012 mm/0.01 unit), volume (Patella: β = - 20.97; LFTC: β = - 21.71 mm3/0.01 unit) and bone area (Patella: β = - 4.39 mm2/0.01 unit). The change in WHR z-scores from childhood to adulthood was negatively associated with cartilage thickness (MFTC: β = - 0.056 mm), volume (patella: - 89.95; LFTC: - 93.98 mm3), and bone area (patella: - 20.74 mm2). All p-values < 0.05.
Conclusions: Childhood weight and BMI were negatively but adult weight was positively associated with adult bone area. Adult WHR and the change in WHR from childhood to adulthood were negatively associated with cartilage thickness, volume, and bone area. These suggest early-life adiposity measures may affect knee structures in young adults.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | obesity, adiposity, cartilage morphology, cartilage thickness, cartilage volume, bone area, young adults |
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Rheumatology and Arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Skeletal System and Disorders (incl. Arthritis) |
| UTAS Author: | Meng, T (Mr Tao Meng) |
| UTAS Author: | Venn, A (Professor Alison Venn) |
| UTAS Author: | Dwyer, T (Professor Terry Dwyer) |
| UTAS Author: | Laslett, LL (Dr Laura Laslett) |
| UTAS Author: | Jones, G (Professor Graeme Jones) |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| UTAS Author: | Antony, B (Dr Benny Eathakkattu Antony) |
| ID Code: | 129016 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 11 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2018-11-01 |
| Last Modified: | 2019-01-18 |
| Downloads: | 63 View Download Statistics |
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