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Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study

Citation

He, Y and Tian, J and Oddy, WH and Dwyer, T and Venn, AJ, Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study, Fertility and Sterility, 110, (4) pp. 596-604.e1. ISSN 0015-0282 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 American Society for Reproductive Medicine

DOI: doi:10.1016/j.fertnstert.2018.05.011

Abstract

Objective: To evaluate whether childhood obesity is associated with infertility in women's reproductive-aged life.

Design: Prospective longitudinal study.

Setting: Not applicable.

Intervention(s): None.

Patient(s): A total of 1,544 girls, aged 7-15 years in 1985, and who completed questionnaires at follow-up in 2004-2006 and/or 2009-2011.

Main outcome measure(s): Infertility was defined as having difficulty conceiving (had tried for ≥12 months to become pregnant without succeeding) or having seen a doctor because of trouble becoming pregnant.

Result(s): At ages from 7-11 years, girls at both the lower and upper end of the body mass index (BMI) z score had increased risk of infertility. Compared with normal weight girls, those with obesity at ages 7-11 years were more likely in adulthood to report infertility (adjusted relative risk [aRR] = 2.94, 95% confidence interval [CI] 1.48-5.84), difficulty conceiving (aRR = 3.89, 95% CI 1.95-7.77), or having seen a doctor because of trouble becoming pregnant (aRR = 3.65, 95% CI 1.90-7.02) after adjusting for childhood age, follow-up length, highest parental education, and marital status.

Conclusion(s): Childhood obesity before 12 years of age appears to increase the risk of female infertility in later life.

Item Details

Item Type:Refereed Article
Keywords:childhood, body composition, body mass index, infertility, waist-to-height ratio
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Preventive Medicine
UTAS Author:He, Y (Ms Ye He)
UTAS Author:Tian, J (Dr Jing Tian)
UTAS Author:Oddy, WH (Professor Wendy Oddy)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Venn, AJ (Professor Alison Venn)
ID Code:128846
Year Published:2018
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-10-17
Last Modified:2018-12-12
Downloads:0

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