He, Y and Tian, J and Oddy, WH and Dwyer, T and Venn, AJ, Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study, Fertility and Sterility, 110, (4) pp. 596-604.e1. ISSN 0015-0282 (2018) [Refereed Article]
Copyright 2018 American Society for Reproductive Medicine
Design: Prospective longitudinal study.
Setting: Not applicable.
Patient(s): A total of 1,544 girls, aged 7-15 years in 1985, and who completed questionnaires at follow-up in 2004-2006 and/or 2009-2011.
Main outcome measure(s): Infertility was defined as having difficulty conceiving (had tried for ≥12 months to become pregnant without succeeding) or having seen a doctor because of trouble becoming pregnant.
Result(s): At ages from 7-11 years, girls at both the lower and upper end of the body mass index (BMI) z score had increased risk of infertility. Compared with normal weight girls, those with obesity at ages 7-11 years were more likely in adulthood to report infertility (adjusted relative risk [aRR] = 2.94, 95% confidence interval [CI] 1.48-5.84), difficulty conceiving (aRR = 3.89, 95% CI 1.95-7.77), or having seen a doctor because of trouble becoming pregnant (aRR = 3.65, 95% CI 1.90-7.02) after adjusting for childhood age, follow-up length, highest parental education, and marital status.
Conclusion(s): Childhood obesity before 12 years of age appears to increase the risk of female infertility in later life.
|Item Type:||Refereed Article|
|Keywords:||childhood, body composition, body mass index, infertility, waist-to-height ratio|
|Research Division:||Health Sciences|
|Research Field:||Epidemiology not elsewhere classified|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Preventive medicine|
|UTAS Author:||He, Y (Ms Ye He)|
|UTAS Author:||Tian, J (Dr Jing Tian)|
|UTAS Author:||Oddy, WH (Professor Wendy Oddy)|
|UTAS Author:||Dwyer, T (Professor Terry Dwyer)|
|UTAS Author:||Venn, AJ (Professor Alison Venn)|
|Web of Science® Times Cited:||11|
|Deposited By:||Menzies Institute for Medical Research|
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