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NLRP3 inflammasome in colitis and colitis-associated colorectal cancer
Citation
Perera, AP and Sajnani, K and Dickinson, J and Eri, R and Korner, H, NLRP3 inflammasome in colitis and colitis-associated colorectal cancer, Mammalian Genome, 29, (11-12) pp. 817-830. ISSN 0938-8990 (2018) [Refereed Article]
Copyright Statement
© Springer Science+Business Media, LLC, part of Springer Nature 2018
DOI: doi:10.1007/s00335-018-9783-2
Abstract
A low level of inflammation is an integral part of the balance between the immune system and the microbiota in the high antigen environment of the gastrointestinal tract and maintains homeostasis. A failure of this balance can lead to chronic intestinal inflammation and increase the chances to develop colorectal cancer significantly. The underlying mechanisms that link inflammation and carcinogenesis are not clear but the molecular platforms of the inflammasomes have been implicated. Inflammasomes are molecule complexes that are assembled in response to microbial components or cellular danger signals and facilitate the production of bioactive pro-inflammatory cytokines. One inflammasome in particular, NLRP3, has been analysed extensively in its contribution to colitis and has been shown to be associated with the development of colitis-associated colorectal cancer. This review will summarise the role of NLRP3 in intestinal inflammation, discuss some of the triggers of inflammation in the gastrointestinal tract such as diet and introduce some opportunities to use this inflammasome as therapeutic target for the treatment of colitis and colitis-associated colorectal cancer.
Item Details
Item Type: | Refereed Article |
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Keywords: | NLRP3 inflammasome, colitis, colorectal cancer, intestinal inflammation |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Cellular immunology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Perera, AP (Mrs Agampodi Perera) |
UTAS Author: | Sajnani, K (Miss Karishma Sajnani) |
UTAS Author: | Dickinson, J (Professor Joanne Dickinson) |
UTAS Author: | Eri, R (Associate Professor Raj Eri) |
UTAS Author: | Korner, H (Professor Heinrich Korner) |
ID Code: | 128638 |
Year Published: | 2018 |
Web of Science® Times Cited: | 3 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-10-04 |
Last Modified: | 2018-12-12 |
Downloads: | 0 |
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