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Cell stress signaling cascades regulating cell fate
Citation
Gundamaraju, R and Vermuri, R and Chong, WC and Geraghty, DP and Eri, R, R Eri, Cell stress signaling cascades regulating cell fate, Current Pharmaceutical Design, 24 pp. 1-8. ISSN 1381-6128 (2018) [Substantial Review]
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DOI: doi:10.2174/1381612824666180711122753
Abstract
© 2018 Bentham Science Publishers. Initiating anti-apoptotic signaling or triggering cell death depends to a great extent on the nature or source of cellular stress and cell type. Interplay between each stress response eventually determines the fate of stressed cell. Numerous factors induce cell death by a number of pathways including apoptosis, autophagy and necrosis. Not surprisingly, some of the pathways are interrelated to each other through a mediator that could articulate the entire mechanism. The present review attempts to consolidate all the pathways included in intrinsic cellular stress such as oxidative stress and autophagy, endoplasmic reticular stress (ERS) and mitophagy and apoptosis as fate in cell stress. These stress responses are a hallmark of numerous diseases including neurodegen-erative diseases, diabetes and cancer. Understanding the cross-talk between different intrinsic cell stress responses will help to develop new therapeutic targets and hence lead to the development of new therapeutics.
Item Details
Item Type: | Substantial Review |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Gastroenterology and hepatology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Gundamaraju, R (Mr Rohit Gundamaraju) |
UTAS Author: | Chong, WC (Mr Wai Chong) |
UTAS Author: | Geraghty, DP (Professor Dominic Geraghty) |
ID Code: | 128624 |
Year Published: | 2018 |
Web of Science® Times Cited: | 3 |
Deposited By: | Health Sciences |
Deposited On: | 2018-10-03 |
Last Modified: | 2019-02-26 |
Downloads: | 0 |
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