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Cell stress signaling cascades regulating cell fate


Gundamaraju, R and Vermuri, R and Chong, WC and Geraghty, DP and Eri, R, R Eri, Cell stress signaling cascades regulating cell fate, Current Pharmaceutical Design, 24 pp. 1-8. ISSN 1381-6128 (2018) [Substantial Review]

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DOI: doi:10.2174/1381612824666180711122753


© 2018 Bentham Science Publishers. Initiating anti-apoptotic signaling or triggering cell death depends to a great extent on the nature or source of cellular stress and cell type. Interplay between each stress response eventually determines the fate of stressed cell. Numerous factors induce cell death by a number of pathways including apoptosis, autophagy and necrosis. Not surprisingly, some of the pathways are interrelated to each other through a mediator that could articulate the entire mechanism. The present review attempts to consolidate all the pathways included in intrinsic cellular stress such as oxidative stress and autophagy, endoplasmic reticular stress (ERS) and mitophagy and apoptosis as fate in cell stress. These stress responses are a hallmark of numerous diseases including neurodegen-erative diseases, diabetes and cancer. Understanding the cross-talk between different intrinsic cell stress responses will help to develop new therapeutic targets and hence lead to the development of new therapeutics.

Item Details

Item Type:Substantial Review
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Gastroenterology and hepatology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Gundamaraju, R (Mr Rohit Gundamaraju)
UTAS Author:Chong, WC (Mr Wai Chong)
UTAS Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:128624
Year Published:2018
Web of Science® Times Cited:4
Deposited By:Health Sciences
Deposited On:2018-10-03
Last Modified:2019-02-26

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