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Mutations in Chromatin Remodeling Factors


Giles, KA and Taberlay, PC, Mutations in Chromatin Remodeling Factors, Encyclopedia of Cancer 3rd Edition, Elsevier, G Pfeifer (ed), United States ISBN 9780128124840 (2018) [Other Book Chapter]

Copyright Statement

Copyright 2018 Elsevier Inc.

DOI: doi:10.1016/B978-0-12-801238-3.65225-X


© 2019 Elsevier Inc. All rights reserved. The nucleosome is a composite of histone proteins and DNA, and is the basic repeating unit of the dynamic, multilayered chromatin structure that dictates the physical organization of DNA inside cells. ATP-dependent chromatin remodeling complexes are responsible for the mobilization of nucleosomes, controlling the compaction and relaxation of chromatin and in turn, accessibility of DNA. There are four structural families of ATP-dependent chromatin remodelers each with unique roles within the cell. All have key roles in essential cellular processes including transcription, DNA replication and DNA repair. Here, we describe these complexes, their individual subunits, and the potential implications for the etiology of cancer when expression and functional activity of these important cellular regulators goes awry.

Item Details

Item Type:Other Book Chapter
Keywords:Chromatin, chromatin remodellers, epigenetics, mutations, cancer
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Epigenetics (incl. genome methylation and epigenomics)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Taberlay, PC (Associate Professor Phillippa Taberlay)
ID Code:128572
Year Published:2018
Funding Support:National Health and Medical Research Council (1109696)
Deposited By:Medicine
Deposited On:2018-10-01
Last Modified:2019-02-14

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