Jelinek, PL and Simpson Jr, S and Brown, CR and Jelinek, GA and Marck, CH and De Livera, AM and O'Kearney, E and Taylor, KL and Neate, SL and Weiland, TJ, Self-reported cognitive function in a large international cohort of people with multiple sclerosis: associations with lifestyle and other factors, European Journal of Neurology pp. 1-13. ISSN 1351-5101 (2018) [Refereed Article]
Copyright 2018 The Authors Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/
Results: The prevalence of PCI in our sample ranged from 41.0% (95% confidence interval, 39.0-43.0) using the least-specific definition to 11.6% (95% confidence interval, 10.3-12.9) using the most specific definition. A number of factors were associated with PCI, increasing in magnitude as the definition specificity increased, including positive associations for smoking and body mass index, whereas physical activity, dietary quality and use of vitamin D/omega-3 supplements were inversely associated with PCI.
Conclusions: Our study reports associations between healthy lifestyle behaviours and PCI in people with MS. Although reverse causality is a potential explanation for our findings, previous studies have shown comparable associations with healthy lifestyle and MS onset and progression. Subject to external validation, these results suggest benefits realized from a healthy lifestyle in people with MS.
|Item Type:||Refereed Article|
|Keywords:||cognitive impairment, epidemiology, lifestyle, multiple sclerosis|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||15 View Download Statistics|
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