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Reduction of a platinum (IV) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation
journal contribution
posted on 2023-05-19, 21:20 authored by Chipman, A, Brian YatesBrian Yates, Allan CantyAllan Canty, Alireza AriafardAlireza AriafardA PtIV prodrug needs to be reduced to PtII by a biomolecule in order to show efficacy. Among biomolecules, those containing an ʟ-Cys residue have the highest potential to be involved in reduction. Tautornerisation from HSCH2CH(NH3+)CO2¯ to the unusual zwitterion form ¯SCH2CH(NH3+)CO2H is the prerequisite for ʟ-Cys to become a potent reductant at a low pH.
History
Publication title
Chemical CommunicationsVolume
54Issue
74Pagination
10491-10494ISSN
1359-7345Department/School
School of Natural SciencesPublisher
Royal Soc ChemistryPlace of publication
Thomas Graham House, Science Park, Milton Rd, Cambridge, England, Cambs, Cb4 0WfRights statement
Copyright 2018 The Royal Society of ChemistryRepository Status
- Restricted