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Modulation of the endocannabinoid system by sex hormones: Implications for Posttraumatic Stress Disorder

Citation

Ney, LJ and Matthews, A and Bruno, R and Felmingham, K, Modulation of the endocannabinoid system by sex hormones: Implications for Posttraumatic Stress Disorder, Neuroscience and Biobehavioral Reviews ISSN 0149-7634 (2018) [Refereed Article]


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DOI: doi:10.1016/j.neubiorev.2018.07.006

Abstract

The endocannabinoid system is an increasingly recognised pharmacological target for treating stress and anxiety disorders, including post-traumatic stress disorder (PTSD). Recent preclinical developments have implicated the endocannabinoid system in stress responses, emotional memories and fear extinction, all critical to PTSD aetiology. However, preclinical research in endocannabinoid biology has neglected the influential role of sex hormone differences on PTSD symptomology, which is particularly important given that PTSD is twice as common in women as in men. In this review, we compile and consider the evidence that the endocannabinoid system is influenced by ovarian hormones, with application to stress disorders such as PTSD. It is clear that therapeutic modulation of the endocannabinoid system needs to be approached with awareness of ovarian hormonal influences, and knowledge of these influences may enhance treatment outcomes for female PTSD populations.

Item Details

Item Type:Refereed Article
Keywords:cannabinoids; cannabis; endocannabinoids; oestrogens; posttraumatic stress disorder; psychiatric disorders; sex differences; translational medical research; traumatic stress
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Mental Health
Author:Ney, LJ (Mr Luke Ney)
Author:Matthews, A (Dr Allison Matthews)
Author:Bruno, R (Associate Professor Raimondo Bruno)
Author:Felmingham, K (Professor Kim Felmingham)
ID Code:128306
Year Published:2018
Deposited By:Psychology
Deposited On:2018-09-12
Last Modified:2018-09-13
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