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Vorapaxar: A novel agent to be considered in the secondary prevention of myocardial infarction
Citation
Obamiro, KO and Kunle, R, Vorapaxar: A novel agent to be considered in the secondary prevention of myocardial infarction, Journal of pharmacy & bioallied sciences, 8, (2) pp. 98-105. ISSN 0976-4879 (2016) [Refereed Article]
Copyright Statement
© Journal of Pharmacy And Bioallied Sciences
DOI: doi:10.4103/0975-7406.171690
Abstract
Patients receiving therapy for the secondary prevention of myocardial infarction (MI) are still at high risk of a major cardiovascular event or death despite the use of currently available treatment strategy. Vorapaxar, an oral protease-activated receptor antagonist, is a novel antiplatelet drug that has been recently approved to provide further risk reduction. The results of two Phase III trials (thrombin receptor antagonists for clinical event reduction and the TRA 2°P-TIMI 50) have showed that vorapaxar, in addition to standard of care therapy, has the potential to provide further risk reduction in patients with prior MI. A search was made on PubMed on articles related to clinical trials and clinical consideration with the use of vorapaxar. This review article summarizes the results of Phase II trials, Phase III trials, subgroup analysis, precautions, and drug interaction with the use of vorapaxar.
Item Details
Item Type: | Refereed Article |
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Keywords: | Antiplatelet, cardiovascular event, myocardial infarction, vorapaxar |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Pharmacology and pharmaceutical sciences |
Research Field: | Clinical pharmacology and therapeutics |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Obamiro, KO (Dr Kehinde Obamiro) |
ID Code: | 128299 |
Year Published: | 2016 |
Deposited By: | UTAS Centre for Rural Health |
Deposited On: | 2018-09-12 |
Last Modified: | 2018-11-26 |
Downloads: | 0 |
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