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Association of depression with mortality in an elderly treated hypertensive population
Citation
Chowdhury, EK and Berk, M and Nelson, MR and Wing, LMH and Reid, CM, Association of depression with mortality in an elderly treated hypertensive population, International Psychogeriatrics, 31, (3) pp. 371-381. ISSN 1041-6102 (2019) [Refereed Article]
Copyright Statement
Copyright 2018 International Psychogeriatric Association
DOI: doi:10.1017/S1041610218000856
Abstract
Methods: Data from 6,083 hypertensive patients aged ≥65 years enrolled in the Second Australian National Blood Pressure study were used. Participants were followed for a median of 10.8 years (including 4.1 years in-trial) and classified into: "no depression," "pre-existing" and "incident" depression groups based on either being "diagnosed with depressive disorders" and/or "treated with an anti-depressant drug" at baseline or during in-trial period. Further, we redefined "depression" restricted to presence of both conditions for sensitivity analyses. For the current study, end-points were all-cause and any cardiovascular mortality.
Results: 313 (5%) participants had pre-existing depression and a further 916 (15%) participants developed depression during the trial period (incidence 4% per annum). Increased (hazard-ratio, 95% confidence-interval) all-cause mortality was observed among those with either pre-existing (1.23, 1.01-1.50; p = 0.03) or incident (1.26, 1.12-1.41; p < 0.001) depression compared to those without. For cardiovascular mortality, a 24% increased risk (1.24, 1.05-1.47; p = 0.01) was observed among those with incident depression. The sensitivity analyses, using the restricted depression definition showed similar associations. Incident depression was associated with being female, aged ≥75 years, being an active smoker at study entry, and developing new diabetes during the study period.
Conclusions: This elderly cohort had a high incidence of depression irrespective of their randomised antihypertensive regimen. Both pre-existing and incident depression were associated with increased mortality.
Item Details
Item Type: | Refereed Article |
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Keywords: | angiotensin converting enzyme inhibitors, depression, diuretics, elderly, hypertension, survival |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Nelson, MR (Professor Mark Nelson) |
ID Code: | 128173 |
Year Published: | 2019 (online first 2018) |
Web of Science® Times Cited: | 2 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-09-06 |
Last Modified: | 2020-06-22 |
Downloads: | 0 |
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