Meng, W and Shah, KP and Pollack, S and Toppila, I and Hebert, HL and McCarthy, MI and Groop, L and Ahlqvist, E and Lyssenko, V and Agardh, E and Daniell, M and Kaidonis, G and Craig, JE and Mitchell, P and Liew, G and Kifley, A and Wang, JJ and Christiansen, MW and Jensen, RA and Penman, A and Hancock, HA and Chen, CJ and Correa, A and Kuo, JZ and Li, X and Chen, Y-der I and Rotter, JI and Klein, R and Klein, B and Wong, TY and Morris, AD and Doney, ASF and Colhoun, HM and Price, AL and Burdon, KP and Groop, P-H and Sandholm, N and Grassi, MA and Sobrin, L and Palmer, CNA, Wellcome Trust Case Control Consortium 2 (WTCCC2), Surrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) study group, A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes, Acta Ophthalmologica, 96, (7) pp. e811-e819. ISSN 1755-375X (2018) [Refereed Article]
Copyright 2018 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Results: Five hundred and sixty cases of type 2 diabetes with severe diabetic retinopathy and 4,106 controls were identified in the GoDARTS cohort. We revealed that rs3913535 in the NADPH Oxidase 4 (NOX4) gene reached a p value of 4.05 × 10-9 . Two nearby SNPs, rs10765219 and rs11018670 also showed promising p values (p values = 7.41 × 10-8 and 1.23 × 10-8, respectively). In the meta-analysis using multiple Caucasian cohorts (excluding GoDARTS), rs10765219 and rs11018670 showed associations for diabetic retinopathy (p = 0.003 and 0.007, respectively), while the p value of rs3913535 was not significant (p = 0.429).
Conclusion: This genome-wide association study of severe diabetic retinopathy suggests new evidence for the involvement of the NOX4 gene.
|Item Type:||Refereed Article|
|Keywords:||NOX4, diabetes, diabetic complications, diabetic retinopathy, genome-wide association study|
|Research Division:||Medical and Health Sciences|
|Research Group:||Ophthalmology and Optometry|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Hearing, Vision, Speech and Their Disorders|
|UTAS Author:||Burdon, KP (Professor Kathryn Burdon)|
|Web of Science® Times Cited:||11|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||32 View Download Statistics|
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