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The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

Citation

Caldwell, A and Coleby, R and Tovar, C and Stammnitz, MR and Kwon, YM and Owen, RS and Tringides, M and Murchison, EP and Skjodt, K and Thomas, GJ and Kaufman, J and Elliott, T and Woods, GM and Siddle, HVT, The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer, Elife, 7 Article e35314. ISSN 2050-084X (2018) [Refereed Article]


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Copyright Statement

Copyright 2018 Caldwell et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.7554/eLife.35314

Abstract

Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1 (DFT1). Here we show that in contrast to DFT1, DFT2 cells express major histocompatibility complex (MHC) class I molecules, demonstrating that loss of MHC is not necessary for the emergence of a contagious cancer. However, the most highly expressed MHC class I alleles in DFT2 cells are common among host devils or non-polymorphic, reducing immunogenicity in a population sharing these alleles. In parallel, MHC class I loss is emerging in vivo, thus DFT2 may be mimicking the evolutionary trajectory of DFT1. Based on these results we propose that contagious cancers may exploit partial histocompatibility between the tumour and host, but that loss of allogeneic antigens could facilitate widespread transmission of DFT2.

Item Details

Item Type:Refereed Article
Keywords:MHC, Sarcophilus harrisii, cancer biology, contagious cancer, immune escape, immunology, inflammation
Research Division:Biological Sciences
Research Group:Zoology
Research Field:Animal Immunology
Objective Division:Environment
Objective Group:Flora, Fauna and Biodiversity
Objective Field:Flora, Fauna and Biodiversity at Regional or Larger Scales
Author:Tovar, C (Dr Cesar Tovar Lopez)
Author:Woods, GM (Professor Gregory Woods)
ID Code:128146
Year Published:2018
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-09-05
Last Modified:2018-10-09
Downloads:11 View Download Statistics

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