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Pulsatile interaction between the macro-vasculature and micro-vasculature: proof-of-concept among patients with type 2 diabetes
Citation
Climie, RED and Picone, DS and Blackwood, S and Keel, SE and Qasem, A and Rattigan, S and Sharman, JE, Pulsatile interaction between the macro-vasculature and micro-vasculature: proof-of-concept among patients with type 2 diabetes, European Journal of Applied Physiology, 118, (11) pp. 2455-2463. ISSN 1439-6319 (2018) [Refereed Article]
Copyright Statement
Copyright 2018 Springer-Verlag GmbH Germany, part of Springer Nature
DOI: doi:10.1007/s00421-018-3972-2
Abstract
Methods: Among 13 T2D (68 ± 6 years, 39% male) and 15 controls (58 ± 11 years, 40% male) macro-vascular stiffness was determined via aortic pulse wave velocity (aPWV) and macro-vascular waveforms were measured using radial tonometry. Forearm micro-vascular waveforms were measured simultaneously with macro-vascular waveforms via low power laser Doppler fluxmetry. Augmentation index (AIx) was derived on macro- and micro-vascular waveforms. Target organ damage was assessed by estimated glomerular filtration rate (eGFR) and central retinal artery equivalent (CRAE).
Results: aPWV was higher among T2D (9.3 ± 2.5 vs 7.5 ± 1.4 m/s, p = 0.046). There was an obvious pulsatile micro-vascular waveform with qualitative features similar to macro-vasculature pressure waveforms. In all subjects, macro- and micro-vasculature AIx were significantly related (r = 0.43, p = 0.005). In T2D alone, micro-vasculature AIx was associated with eGFR (r = - 0.63, p = 0.037), whereas in controls, macro-vasculature AIx and AP were associated with CRAE (r = - 0.58, p = 0.025 and r = - 0.61, p = 0.015).
Conclusions: Macro- and micro-vasculature waveform features are related; however, micro-vasculature features are more closely related to markers of target organ damage in T2D. These findings are suggestive of a possible interaction between the macro- and micro-circulation.
Item Details
Item Type: | Refereed Article |
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Keywords: | aorta, arterial stiffness, blood pressure, physiology |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Endocrinology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Climie, RED (Dr Rachel Climie) |
UTAS Author: | Picone, DS (Dr Dean Picone) |
UTAS Author: | Blackwood, S (Ms Sarah Blackwood) |
UTAS Author: | Rattigan, S (Professor Stephen Rattigan) |
UTAS Author: | Sharman, JE (Professor James Sharman) |
ID Code: | 128122 |
Year Published: | 2018 |
Web of Science® Times Cited: | 11 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-09-04 |
Last Modified: | 2019-03-25 |
Downloads: | 0 |
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