Climie, RED and Picone, DS and Blackwood, S and Keel, SE and Qasem, A and Rattigan, S and Sharman, JE, Pulsatile interaction between the macro-vasculature and micro-vasculature: proof-of-concept among patients with type 2 diabetes, European Journal of Applied Physiology, 118, (11) pp. 2455-2463. ISSN 1439-6319 (2018) [Refereed Article]
Copyright 2018 Springer-Verlag GmbH Germany, part of Springer Nature
Methods: Among 13 T2D (68 ± 6 years, 39% male) and 15 controls (58 ± 11 years, 40% male) macro-vascular stiffness was determined via aortic pulse wave velocity (aPWV) and macro-vascular waveforms were measured using radial tonometry. Forearm micro-vascular waveforms were measured simultaneously with macro-vascular waveforms via low power laser Doppler fluxmetry. Augmentation index (AIx) was derived on macro- and micro-vascular waveforms. Target organ damage was assessed by estimated glomerular filtration rate (eGFR) and central retinal artery equivalent (CRAE).
Results: aPWV was higher among T2D (9.3 ± 2.5 vs 7.5 ± 1.4 m/s, p = 0.046). There was an obvious pulsatile micro-vascular waveform with qualitative features similar to macro-vasculature pressure waveforms. In all subjects, macro- and micro-vasculature AIx were significantly related (r = 0.43, p = 0.005). In T2D alone, micro-vasculature AIx was associated with eGFR (r = - 0.63, p = 0.037), whereas in controls, macro-vasculature AIx and AP were associated with CRAE (r = - 0.58, p = 0.025 and r = - 0.61, p = 0.015).
Conclusions: Macro- and micro-vasculature waveform features are related; however, micro-vasculature features are more closely related to markers of target organ damage in T2D. These findings are suggestive of a possible interaction between the macro- and micro-circulation.
|Item Type:||Refereed Article|
|Keywords:||aorta, arterial stiffness, blood pressure, physiology|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|UTAS Author:||Climie, RED (Miss Rachel Climie)|
|UTAS Author:||Picone, DS (Mr Dean Picone)|
|UTAS Author:||Blackwood, S (Ms Sarah Blackwood)|
|UTAS Author:||Rattigan, S (Professor Stephen Rattigan)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|Web of Science® Times Cited:||7|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page