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Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases
Citation
Tai, Y and Wang, Q and Korner, H and Zhang, L and Wei, W, Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases, Frontiers in Pharmacology, 9, (June) Article 642. ISSN 1663-9812 (2018) [Refereed Article]
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Copyright Statement
Copyright 2018 Tai, Wang, Korner, Zhang and Wei. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.3389/fphar.2018.00642
Abstract
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two activating signals are necessary steps that lead to T cell activation. The formation of stimulatory IS involves the inclusion of costimulatory molecules, such as ICAM-1/LFA-1 and CD28/B7-1, and so on. Some fusion proteins and monoclonal antibodies targeting costimulatory molecules have been developed and approved to treat autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), type I diabetes (T1D), inflammatory bowel disease (IBD), and psoriasis. These biological agents, including CTLA-4- and LFA-3-Ig, anti-CD3 monoclonal antibody, could prevent the successful engagement of DCs by T cell with significant efficacy and safety profile. In this article, we reviewed the molecular mechanisms of T cell activation during the interaction between T cells and DCs, and summarized some biological agents that target costimulatory molecules involved in the regulation of T cell activation.
Item Details
Item Type: | Refereed Article |
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Keywords: | T cell, activation, autoimmune diseases, biological agents, dendritic cells, immunological synapse |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Immunology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Korner, H (Professor Heinrich Korner) |
ID Code: | 128071 |
Year Published: | 2018 |
Web of Science® Times Cited: | 81 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-08-30 |
Last Modified: | 2022-08-25 |
Downloads: | 154 View Download Statistics |
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