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Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke
Citation
McCann, SK and Sena, ES and Currie, GL and Macleod, MR and Howells, DW, Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke, Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchak and JH Zhang (ed), Switzerland, pp. 73-93. ISBN 978-3-319-45344-6 (2017) [Research Book Chapter]
Copyright Statement
Copyright 2017 Springer
DOI: doi:10.1007/978-3-319-45345-3_2
Abstract
Animal models of ischaemic stroke have become an integral part of the preclinical pipeline for identifying novel neuroprotective drug targets and drugs. As the process serves as a filter, researchers do not expect complete concordance between the experimental animal and human clinical trial data. However, the paucity of clear examples of translation of promising animal results into drugs that work in a clinical setting has raised concerns about the utility of this translational paradigm. Preclinical systematic reviews have been used in response to these concerns to identify weaknesses in animal studies and provide empirical evidence supporting improvements to the design and conduct of preclinical animal experiments. We propose that further strategic development and application of data analysis methods can help continue this process of improvement and help identify the most promising therapeutic targets and drugs. These next steps in systematic review aim to tighten the focus of preclinical research, streamline the drug development process, and minimise research waste.
Item Details
Item Type: | Research Book Chapter |
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Keywords: | stroke, preclinical systematic review, meta-analysis, translational research, bias |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurology and neuromuscular diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Howells, DW (Professor David Howells) |
ID Code: | 128038 |
Year Published: | 2017 |
Deposited By: | Medicine |
Deposited On: | 2018-08-28 |
Last Modified: | 2018-09-06 |
Downloads: | 0 |
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