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Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke


McCann, SK and Sena, ES and Currie, GL and Macleod, MR and Howells, DW, Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke, Neuroprotective Therapy for Stroke and Ischemic Disease, Springer International Publishing, PA Lapchak and JH Zhang (ed), Switzerland, pp. 73-93. ISBN 978-3-319-45344-6 (2017) [Research Book Chapter]

Copyright Statement

Copyright 2017 Springer

DOI: doi:10.1007/978-3-319-45345-3_2


Animal models of ischaemic stroke have become an integral part of the preclinical pipeline for identifying novel neuroprotective drug targets and drugs. As the process serves as a filter, researchers do not expect complete concordance between the experimental animal and human clinical trial data. However, the paucity of clear examples of translation of promising animal results into drugs that work in a clinical setting has raised concerns about the utility of this translational paradigm. Preclinical systematic reviews have been used in response to these concerns to identify weaknesses in animal studies and provide empirical evidence supporting improvements to the design and conduct of preclinical animal experiments. We propose that further strategic development and application of data analysis methods can help continue this process of improvement and help identify the most promising therapeutic targets and drugs. These next steps in systematic review aim to tighten the focus of preclinical research, streamline the drug development process, and minimise research waste.

Item Details

Item Type:Research Book Chapter
Keywords:stroke, preclinical systematic review, meta-analysis, translational research, bias
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Howells, DW (Professor David Howells)
ID Code:128038
Year Published:2017
Deposited By:Medicine
Deposited On:2018-08-28
Last Modified:2018-09-06

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