Abdollahpour, I and Nedjat, S and Mansournia, MA and Sahraian, MA and van der Mei, I, Lifestyle factors and multiple sclerosis: a population-based incident case-control study, Multiple Sclerosis and Related Disorders, 22 pp. 128-133. ISSN 2211-0348 (2018) [Refereed Article]
Copyright 2018 Published by Elsevier B.V.
Materials and Methods: This was population-based incident case-control study in Iran with 547 incident cases and 1057 general population controls (7/8/2013-17/2/2015). Logistic regression was used to analyse the data.
Results: Higher sun exposure during adolescence was associated with a reduced risk of MS, both in summer (test for trend p < 0.001) and winter (P < 0.001), while physical activity was not associated with MS (test for trend p = 0.712). Lifetime drug abuse (OR for ever use 2.93 (1.83-4.70)), with a dose-response association (test for trend p < 0.001), and alcohol intake (OR for ever use 1.49 (1.05-2.12)) was significantly associated with an increased risk of MS.
Conclusion: In a middle-eastern setting, we found that sun exposure during adolescence, drug abuse, and alcohol use were all associated with MS. Increasing sun exposure and reducing drug abuse and the use of alcohol through educational programs is likely to reduce the rate of MS.
|Item Type:||Refereed Article|
|Keywords:||alcohol, case-control, drug abuse, lifestyle factors, multiple sclerosis, physical activity, sun exposure|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|UTAS Author:||van der Mei, I (Associate Professor Ingrid van der Mei)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
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