Medina, DAV and Santos-Neto, AJ and Cerda, V and Maya, F, Automated dispersive liquid-liquid microextraction based on the solidification of the organic phase, Talanta, 189 pp. 241-248. ISSN 0039-9140 (2018) [Refereed Article]
Copyright 2018 Elsevier B.V.
In this work, the dispersive liquid-liquid microextraction technique based on the solidification of the organic phase (DLLME-SFO) has been automated for the first time. DLLME-SFO is automated by hyphenating a sequential injection analysis (SIA) system with a custom-made robotic phase separator. Automated in-syringe DLLME is followed by phase separation in a 3D printed device integrating a Peltier cell set, mounted on a multi-axis robotic arm. The combined action of the flow system and the robotic arm is controlled by a single software package, enabling the solidification/melting and collection of the organic phase for further analyte quantification.
As proof-of-concept, automated DLLME-SFO was applied to the extraction of parabens followed by separation using liquid chromatography, obtaining LODs between 0.3 and 1.3 µg L−1 (4 mL of sample extracted in 1 mL of 1-dodecanol: MeOH, 15:85, v-v). The method showed a high reproducibility, obtaining intraday RSDs between 4.6% and 5.8% (n = 6), and interday RSDs between 5.6% and 8.6% (n = 6). The developed method was evaluated for the determination of parabens in water, urine, saliva, and personal care products.
|Item Type:||Refereed Article|
|Keywords:||3D printing, flow analysis, dispersive liquid-liquid microextraction, solidification of the organic phase, in-syringe extraction, open-source robotics|
|Research Division:||Chemical Sciences|
|Research Group:||Analytical Chemistry|
|Research Field:||Flow Analysis|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding Knowledge|
|Objective Field:||Expanding Knowledge in the Chemical Sciences|
|UTAS Author:||Maya, F (Mr Fernando Maya Alejandro)|
|Web of Science® Times Cited:||6|
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