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Progress in the development of Platelet-Activating Factor Receptor (PAFr) antagonists and applications in the treatment of inflammatory diseases
Citation
Hyland, IK and O'Toole, RF and Smith, JA and Bissember, AC, Progress in the development of Platelet-Activating Factor Receptor (PAFr) antagonists and applications in the treatment of inflammatory diseases, ChemMedChem, 13, (18) pp. 1873-1884. ISSN 1860-7179 (2018) [Refereed Article]
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Copyright Statement
Copyright 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: doi:10.1002/cmdc.201800401
Abstract
Platelet-activating factor (PAF) and its receptor (PAFr) have been implicated in a wide range of diseases and disorders that originate from the activation of inflammatory pathways. Although the exact structure of the binding site on the PAFr remains unknown, the PAFr is a well-established therapeutic target, and an array of structurally diverse PAFr antagonists have been identified. These include compounds that are structurally similar to the natural PAF ligand, synthetic heterocycles, complex polycyclic natural products, and various metal complexes. This review provides an update on more than 20 years of progress in this area. The development and synthesis of new PAFr antagonists, structure-activity relationship studies, the biological activity of these molecules, and their therapeutic potential are discussed.
Item Details
Item Type: | Refereed Article |
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Keywords: | ginkgolides, inflammatory diseases, platelet-activating factor, thienodiazepines, xanthones |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical microbiology |
Research Field: | Medical bacteriology |
Objective Division: | Manufacturing |
Objective Group: | Human pharmaceutical products |
Objective Field: | Human pharmaceutical treatments |
UTAS Author: | Hyland, IK (Ms Isabel Hyland) |
UTAS Author: | O'Toole, RF (Dr Ronan O'Toole) |
UTAS Author: | Smith, JA (Associate Professor Jason Smith) |
UTAS Author: | Bissember, AC (Associate Professor Alex Bissember) |
ID Code: | 127815 |
Year Published: | 2018 |
Web of Science® Times Cited: | 14 |
Deposited By: | Medicine |
Deposited On: | 2018-08-17 |
Last Modified: | 2019-12-03 |
Downloads: | 9 View Download Statistics |
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