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Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network
Citation
Karch, CM and Hernandez, D and Wang, J-C and Marsh, J and Hewitt, AW and Hsu, S and Norton, J and Levitch, D and Donahue, T and Sigurdson, W and Ghetti, B and Farlow, M and Chhatwal, J and Berman, S and Cruchaga, C and Morris, JC and Bateman, RJ and Pebay, A and Goate, AM and the Dominantly Inherited Alzheimer Network (DIAN), Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network, Alzheimer's Research and Therapy, 10, (1) Article 69. ISSN 1758-9193 (2018) [Refereed Article]
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Copyright Statement
© 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1186/s13195-018-0400-0
Abstract
Results: We generated a library of 98 dermal fibroblast lines from 42 ADAD families enrolled in DIAN. We have reprogrammed a subset of the DIAN fibroblast lines into patient-specific induced pluripotent stem cell (iPSC) lines. These cells were thoroughly characterized for pluripotency markers.
Conclusions: This library represents a comprehensive resource that can be used for disease modeling and the development of novel therapeutics.
Item Details
Item Type: | Refereed Article |
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Keywords: | amyloid precursor protein, Dominantly Inherited Alzheimer Network, fibroblasts, induced pluripotent stem cells, presenilin 1, presenilin 2 |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurology and neuromuscular diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Hewitt, AW (Professor Alex Hewitt) |
ID Code: | 127798 |
Year Published: | 2018 |
Web of Science® Times Cited: | 6 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-08-16 |
Last Modified: | 2019-02-25 |
Downloads: | 52 View Download Statistics |
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