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Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease
Citation
Wilkinson, R and Lyons, AB and Roberts, D and Wong, M-X and Bartley, PA and Jackson, DE, Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease, Blood, 100, (1) pp. 184-193. ISSN 0006-4971 (2002) [Refereed Article]
Copyright Statement
© 2002 by The American Society of Hematology
DOI: doi:10.1182/blood-2002-01-0027
Abstract
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an immunoglobulin-immunoreceptor tyrosine-based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, SHP-1 and SHP-2, through its intrinsic ITIMs. PECAM-1-deficient (PECAM-1(-/-) ) mice exhibit a hyperresponsive B-cell phenotype, increased numbers of B-1 cells, reduced B-2 cells, and develop autoantibodies. In the periphery, there are reduced mature recirculating B-2 cells and increased B-1a cells within the peritoneal cavity. In addition, PECAM-1(-/-) B cells display hyperproliferative responses to lipopolysaccharide and anti-IgM stimulation and showed enhanced kinetics in their intracellular Ca(++) response following IgM cross-linking. PECAM-1(-/-) mice showed increased serum levels of IgM with elevated IgG isotypes and IgA antidinitrophenol antibody in response to the T-independent antigen, dinitrophenol-Ficoll. Finally, PECAM-1(-/-) mice developed antinuclear antibodies and lupuslike autoimmune disease with age.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | B cell function, autoimmunity |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Cellular immunology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Lyons, AB (Associate Professor Bruce Lyons) |
| ID Code: | 127629 |
| Year Published: | 2002 |
| Web of Science® Times Cited: | 84 |
| Deposited By: | Medicine |
| Deposited On: | 2018-08-07 |
| Last Modified: | 2018-09-18 |
| Downloads: | 0 |
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