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Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease

journal contribution
posted on 2023-05-19, 20:07 authored by Wilkinson, R, Alan Lyons, Roberts, D, Wong, M-X, Bartley, PA, Jackson, DE
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an immunoglobulin-immunoreceptor tyrosine-based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, SHP-1 and SHP-2, through its intrinsic ITIMs. PECAM-1-deficient (PECAM-1(-/-) ) mice exhibit a hyperresponsive B-cell phenotype, increased numbers of B-1 cells, reduced B-2 cells, and develop autoantibodies. In the periphery, there are reduced mature recirculating B-2 cells and increased B-1a cells within the peritoneal cavity. In addition, PECAM-1(-/-) B cells display hyperproliferative responses to lipopolysaccharide and anti-IgM stimulation and showed enhanced kinetics in their intracellular Ca(++) response following IgM cross-linking. PECAM-1(-/-) mice showed increased serum levels of IgM with elevated IgG isotypes and IgA antidinitrophenol antibody in response to the T-independent antigen, dinitrophenol-Ficoll. Finally, PECAM-1(-/-) mice developed antinuclear antibodies and lupuslike autoimmune disease with age.

History

Publication title

Blood

Volume

100

Pagination

184-193

ISSN

0006-4971

Department/School

Tasmanian School of Medicine

Publisher

Amer Soc Hematology

Place of publication

1900 M Street. Nw Suite 200, Washington, USA, Dc, 20036

Rights statement

© 2002 by The American Society of Hematology

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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