eCite Digital Repository

Medication regimen complexity and hospital readmission in older adults with chronic kidney disease


Tesfaye, W and Peterson, GM and Castelino, RL and McKercher, CM and Jose, MD and Wimmer, BC and Zaidi, STR, Medication regimen complexity and hospital readmission in older adults with chronic kidney disease, The Annals of Pharmacotherapy, 53, (1) pp. 28-34. ISSN 1060-0280 (2019) [Refereed Article]

Copyright Statement

Copyright 2018 The Authors

DOI: doi:10.1177/1060028018793419


Background: Chronic kidney disease (CKD) is characterized by high rates of hospital admissions and readmissions. However, there is a scarcity of research into medication-related factors predicting such outcomes in this patient group.

Objective: To evaluate the effect of medication regimen complexity at hospital discharge on subsequent readmissions and their timing in older adults with CKD.

Methods: This was a 12-month retrospective cohort study of 204 older (⩾65 years) CKD patients in an Australian tertiary care hospital. Medication regimen complexity was quantified using the 65- item medication regimen complexity index (MRCI). The outcomes were the occurrence of readmission in 30 days and time to readmission within 12 months. Logistic regression was used to identify factors predicting 30-day readmission, and a competing risks proportional subdistribution hazard model, accounting for deaths, was used for factors predicting time to readmission.

Results: Overall, 50 (24%) patients, predominantly men (72%), were readmitted within 30 days of follow-up. MRCI was not significantly associated with 30-day readmission (odds ratio [OR] = 1.27; 95% CI = 0.94-1.73). The median (interquartile range) time to readmission within 12 months was 145 (31-365) days. On a multivariate analysis, a 10-unit increase in MRCI was associated with a shorter time to readmission within 12 months (subdistribution HR = 1.18; 95% CI = 1.01-1.36).

Conclusion and Relevance: Medication regimen complexity was not significantly associated with 30-day readmission; however, it was associated with a significantly shorter time to 12-month readmission in older CKD patients. This finding highlights the importance of medication regimen complexity as a potential target for medical interventions to reduce readmission risks.

Item Details

Item Type:Refereed Article
Keywords:medication use, medication regimen complexity, chronic kidney disease, hospital readmission, elderly, predictors
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Tesfaye, W (Mr Wubshet Tesfaye)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Castelino, RL (Dr Ronald Castelino)
UTAS Author:McKercher, CM (Dr Charlotte McKercher)
UTAS Author:Jose, MD (Professor Matthew Jose)
UTAS Author:Wimmer, BC (Dr Barbara Wimmer)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
ID Code:127555
Year Published:2019 (online first 2018)
Web of Science® Times Cited:8
Deposited By:Pharmacy
Deposited On:2018-08-03
Last Modified:2019-02-22

Repository Staff Only: item control page