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Sex differences in the evaluation and treatment of acute ischaemic stroke


Bushnell, C and Howard, VJ and Lisabeth, L and Caso, V and Gall, S and Kleindorfer, D and Chaturvedi, S and Madsen, TE and Demel, SL and Lee, S-J and Reeves, M, Sex differences in the evaluation and treatment of acute ischaemic stroke, The Lancet Neurology, 17, (7) pp. 641-650. ISSN 1474-4422 (2018) [Refereed Article]

Copyright Statement

2018 Elsevier Ltd.

DOI: doi:10.1016/S1474-4422(18)30201-1


With the greater availability of treatments for acute ischaemic stroke, including advances in endovascular therapy, personalised assessment of patients before treatment is more important than ever. Women have a higher lifetime risk of stroke; therefore, reducing potential sex differences in the acute stroke setting is crucial for the provision of equitable and fast treatment. Evidence indicates sex differences in prevalence and types of non-traditional stroke symptoms or signs, prevalence of stroke mimics, and door-to-imaging times, but no substantial differences in use of emergency medical services, stroke knowledge, eligibility for or access to thrombolysis or thrombectomy, or outcomes after either therapy. Women presenting with stroke mimics or non-traditional stroke symptoms can be misdiagnosed, which can lead to inappropriate triage, and acute treatment delays. It is essential for health-care providers to recognise possible sex differences in stroke symptoms, signs, and mimics. Future studies focused on confounders that affect treatment and outcomes, such as age and pre-stroke function, are also needed.

Item Details

Item Type:Refereed Article
Keywords:zoledronic acid, osteoarthritis, cartilage, pain, magnetic resonance imaging (MRI)
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Gall, S (Associate Professor Seana Gall)
ID Code:127413
Year Published:2018
Web of Science® Times Cited:58
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-07-26
Last Modified:2019-02-25

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