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Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective


Vemuri, R and Gundamaraju, R and Shastri, MD and Shukla, SD and Kalpurath, K and Ball, M and Tristram, S and Shankar, EM and Ahuja, K and Eri, R, Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective, BioMed Research International, 2018 Article 4178607. ISSN 2314-6133 (2018) [Refereed Article]


Copyright Statement

Copyright 2018 Ravichandra Vemuri et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1155/2018/4178607


Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora. Advanced age, antibiotic use, underlying diseases, infections, hormonal differences, circadian rhythm, and malnutrition, either alone or in combination, contribute to the problem. This nonbeneficial gastrointestinal modulation may be reversed by judicious and controlled use of antibiotics and the appropriate use of prebiotics and probiotics. In certain persistent, recurrent settings, the option of faecal microbiota transplantation can be explored. The aim of the current review is to focus on the establishment and alteration of gut microbiota, with ageing. The review also discusses the potential role of gut microbiota in regulating the immune system, together with its function in healthy and diseased state.

Item Details

Item Type:Refereed Article
Keywords:gut microbiota, ageing, probiotics
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Microbial ecology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:Gundamaraju, R (Mr Rohit Gundamaraju)
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Shukla, SD (Mr Shakti Shukla)
UTAS Author:Tristram, S (Dr Stephen Tristram)
UTAS Author:Ahuja, K (Dr Kiran Ahuja)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:127170
Year Published:2018
Web of Science® Times Cited:60
Deposited By:Health Sciences
Deposited On:2018-07-16
Last Modified:2019-12-03
Downloads:78 View Download Statistics

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