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Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial

Citation

Zheng, S and Wang, B and Han, W and Zhu, Z and Wang, X and Jin, X and Antony, B and Cicuttini, F and Wluka, A and Winzenberg, T and Aitken, D and Blizzard, L and Jones, G and Ding, C, Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial, British Journal of Nutrition, 120, (1) pp. 41-48. ISSN 0007-1145 (2018) [Refereed Article]


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Copyright 2018 The Authors

DOI: doi:10.1017/S0007114518001174

Abstract

The aim of this study was to determine whether vitamin D supplementation and maintaining vitamin D sufficiency are associated with changes in inflammatory and metabolic biomarkers in patients with knee osteoarthritis (OA) and vitamin D deficiency. A total of 413 participants with symptomatic knee OA and vitamin D deficiency were enrolled in a randomised, placebo-controlled trial and received 125 mg vitamin D3 or placebo monthly for 24 months across two sites. In this post hoc analysis, 200 participants from one site (ninety-four from the placebo group and 106 from the vitamin D group; mean age 631 (SD 73) years, 533% women) were randomly selected for measurement of serum levels of inflammatory and metabolic biomarkers at baseline and 24 months using immunoassays. In addition, participants were classified into two groups according to serum 25-hydroxyvitamin D (25(OH)D) levels at months 3 and 24: (1) not consistently sufficient (25(OH)D≤50 nmol/l at either month 3 or 24, n 61), and (2) consistently sufficient (25(OH)D >50 nmol/l at both months 3 and 24, n 139). Compared with placebo, vitamin D supplementation had no significant effect on change in serum high-sensitive C-reactive protein, IL-6, IL-8, IL-10, leptin, adiponectin, resistin, adipsin and apelin. Being consistently vitamin D sufficient over 2 years was also not associated with changes in these biomarkers compared with not being consistently sufficient. Vitamin D supplementation and maintaining vitamin D sufficiency did not alter serum levels of inflammatory and metabolic biomarkers over 2 years in knee OA patients who were vitamin D insufficient, suggesting that they may not affect systemic inflammation in knee OA patients.

Item Details

Item Type:Refereed Article
Keywords:vitamin D, inflammation, biomarkers, knee osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Zheng, S (Miss Shuang Zheng)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Zhu, Z (Mr Zhaohua Zhu)
UTAS Author:Wang, X (Ms Xia Wang)
UTAS Author:Jin, X (Mr Xingzhong Jin)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:127152
Year Published:2018
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-07-13
Last Modified:2019-03-05
Downloads:24 View Download Statistics

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