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Therapeutic potential of enoxaparin in Lichen planus: exploring reasons for inconsistent reports

Citation

Patel, RP and Shastri, MD and Ming, LC and Zaidi, STR and Peterson, GM, Therapeutic potential of enoxaparin in Lichen planus: exploring reasons for inconsistent reports, Frontiers in Pharmacology, 9 Article 586. ISSN 1663-9812 (2018) [Refereed Article]


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Copyright Statement

Copyright 2018 Patel, Shastri, Ming, Zaidi and Peterson. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fphar.2018.00586

Abstract

Lichen planus (LP) is an uncommon mucocutaneous inflammatory condition, that is immunologically mediated, typically pruritic and often recurs. The currently advocated therapies are either not highly effective or associated with severe side effects. Enoxaparin, a widely used anticoagulant, is composed of both anticoagulant and non-anticoagulant fragments. Enoxaparin is reported to have anti-inflammatory properties and it was found to be effective in LP. However, the results from clinical studies have varied substantially and, therefore, the clinical role of enoxaparin in LP remains uncertain. This review focuses on potential reasons for the reported inconsistent outcomes, as well as proposing solutions; these include identifying batch-to-batch inconsistency in the composition of enoxaparin. The potential therapeutic value of enoxaparin in LP must be explored using well-designed clinical trials, combined with experimental studies that focus on identifying the anti-inflammatory fragments of enoxaparin and elucidating the mechanism of action of these non-anticoagulant fragments.

Item Details

Item Type:Refereed Article
Keywords:Lichen planus enoxaparin heparin
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Clinical Pharmacology and Therapeutics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skin and Related Disorders
Author:Patel, RP (Dr Rahul Patel)
Author:Shastri, MD (Mr Madhur Shastri)
Author:Ming, LC (Dr Long Ming)
Author:Zaidi, STR (Dr Tabish Razi Zaidi)
Author:Peterson, GM (Professor Gregory Peterson)
ID Code:127118
Year Published:2018
Deposited By:College Office - CHM
Deposited On:2018-07-11
Last Modified:2018-10-31
Downloads:8 View Download Statistics

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