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FDG PET in Staging of Oesophageal Cancer - Results in 131 Patients

Citation

Lenzo, NP and Butler-Henderson, K and McCarthy, M, FDG PET in Staging of Oesophageal Cancer - Results in 131 Patients, European Journal of Nuclear Medicine and Molecular Imaging, September, pp. S19. ISSN 1619-7070 (2005) [Conference Extract]


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DOI: doi:10.1007/s00259-005-1940-7

Abstract

INTRODUCTION: Conventional staging with CT and endoscopic ultrasound is reported to inappropriately stage 18-29% of oesophageal cancer patients. Despite technical difficulties with FDG PET, studies to date suggest a benefit of this technology in more accurately staging oesophageal cancer.METHODS: From November 2002 to March 2005, 131 patients referred for primary staging of diagnosed oesophageal cancer (on endoscopy and biopsy) were prospectively evaluated using FDG PET. Whole body images were obtained on a GSO Philips Allegro PET scanner 45 minutes after injection of FDG. Demographic data, staging based on conventional imaging and the referring clinicians management plan were obtained pre-PET. Post-PET were compared with post-PET findings. Follow-up was obtained on a subgroup of 33 patients.RESULTS: In the cohort studied there was no significant change in T or N staging by FDG PET compared with conventional staging with CT and endoscopic ultrasound. There was however an increase of patients with definite/known metastatic disease from 7% pre-PET to 25% post-PET. In a sub-group of 33 patients with management plan follow up, 21% had a change in management which was actively pursued post-PET. CONCLUSION: FDG PET more accurately staged oesophageal cancer based on the detection of previously unknown metastatic disease. FDG PET did not change T or N staging compared with conventional staging. Finally FDG PET changed management in one out of 5 patients of a cohort subgroup. FDG PET should be considered as part of the standard staging algorithm for oesophageal cancer.

Item Details

Item Type:Conference Extract
Keywords:positron emission tomography, oesophageal cancer
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Oncology and Carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Butler-Henderson, K (Dr Kerryn Butler-Henderson)
ID Code:127046
Year Published:2005
Deposited By:Tasmanian School of Business and Economics
Deposited On:2018-07-06
Last Modified:2018-07-09
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