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Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative
Citation
Wang, K and Ding, C and Hannon, MJ and Chen, Z and Kwoh, CK and Lynch, J and Hunter, DJ, Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative, Osteoarthritis and Cartilage, 26, (10) pp. 1345-1350. ISSN 1063-4584 (2018) [Refereed Article]
Copyright Statement
Copyright 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
DOI: doi:10.1016/j.joca.2018.05.015
Abstract
Design: The subjects were selected from Osteoarthritis Initiative (OAI) study. Case knees (n = 127) were defined as those who received KR during 5 years follow-up visit. They were matched by gender, age and radiographic status with control knees (n = 127). We used T2-weighted MR images to measure IPFP SI alteration using a newly developed algorithm in MATLAB. The measurements were assessed at baseline (BL), T0 (the visit just before KR) and 1 year before T0 (T-1). Conditional logistic regression was used to analyse the associations between IPFP SI alterations and the risk of KR.
Results: Participants were mostly female (57%), with an average age of 63.7 years old and a mean body mass index (BMI) of 29.5 kg/m2. In multivariable analysis, the standard deviation (SD) of IPFP SI [sDev (IPFP)] and the ratio of high SI region volume to whole IPFP volume [Percentage (H)] measured at BL were significantly associated with increased risks of KR after adjustment for covariates. IPFP SI alterations measured at T-1 including sDev (IPFP), Percentage (H) and clustering effect of high SI [Clustering factor (H)] were significantly associated with higher risks of KR. All measurements were significantly associated with higher risks of KR at T0.
Conclusions: IPFP SI is associated with the occurrence of KR suggesting it may play a role in end-stage knee OA.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | epidemiology, infrapatellar fat pad, magnetic resonance imaging, osteoarthritis |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Rheumatology and arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Wang, K (Dr Kun Wang) |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| UTAS Author: | Chen, Z (Dr Zhongshan Chen) |
| ID Code: | 126980 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 6 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2018-07-05 |
| Last Modified: | 2019-03-15 |
| Downloads: | 0 |
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