Wang, K and Ding, C and Hannon, MJ and Chen, Z and Kwoh, CK and Lynch, J and Hunter, DJ, Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative, Osteoarthritis and Cartilage, 26, (10) pp. 1345-1350. ISSN 1063-4584 (2018) [Refereed Article]
Copyright 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Design: The subjects were selected from Osteoarthritis Initiative (OAI) study. Case knees (n = 127) were defined as those who received KR during 5 years follow-up visit. They were matched by gender, age and radiographic status with control knees (n = 127). We used T2-weighted MR images to measure IPFP SI alteration using a newly developed algorithm in MATLAB. The measurements were assessed at baseline (BL), T0 (the visit just before KR) and 1 year before T0 (T-1). Conditional logistic regression was used to analyse the associations between IPFP SI alterations and the risk of KR.
Results: Participants were mostly female (57%), with an average age of 63.7 years old and a mean body mass index (BMI) of 29.5 kg/m2. In multivariable analysis, the standard deviation (SD) of IPFP SI [sDev (IPFP)] and the ratio of high SI region volume to whole IPFP volume [Percentage (H)] measured at BL were significantly associated with increased risks of KR after adjustment for covariates. IPFP SI alterations measured at T-1 including sDev (IPFP), Percentage (H) and clustering effect of high SI [Clustering factor (H)] were significantly associated with higher risks of KR. All measurements were significantly associated with higher risks of KR at T0.
Conclusions: IPFP SI is associated with the occurrence of KR suggesting it may play a role in end-stage knee OA.
|Item Type:||Refereed Article|
|Keywords:||epidemiology, infrapatellar fat pad, magnetic resonance imaging, osteoarthritis|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Wang, K (Dr Kun Wang)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|UTAS Author:||Chen, Z (Dr Zhongshan Chen)|
|Web of Science® Times Cited:||6|
|Deposited By:||Menzies Institute for Medical Research|
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