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Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets

Citation

Eapen, MS and Sohal, SS, Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets, Clinical science, 132, (3) pp. 375-379. ISSN 0143-5221 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society

DOI: doi:10.1042/CS20171261

Abstract

Airway infections are considered as one of the vital factors driving the pathophysiology of chronic lung disease with significant influences on disease trajectory. Opportunistic lung microbes in diseased conditions induce excessive exacerbations and contribute to airflow limitation. Though there has been considerable amount of information that ascertains their links with airway inflammation, the intricate interaction in clinical conditions are poorly understood and requires further deciphering. Current therapeutic interventions for such pathologies are few and lack the ability to modulate underlying dysfunctional immunity as well as suppress the excessive infectious conditions. Thus, in this Commentary we provide a focused outlook on the mechanisms involved in microbial infestation in lung diseases and provides important information on new therapeutic interventions including the potential role of Resolvins and their derivatives as alternative therapeutic agents in combating such multifaceted pathological mechanisms.

Item Details

Item Type:Refereed Article
Keywords:COPD, infection, inflammation, Pneumonia
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Eapen, MS (Mr Mathew Eapen)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:126892
Year Published:2018
Web of Science® Times Cited:7
Deposited By:Health Sciences
Deposited On:2018-07-02
Last Modified:2018-11-29
Downloads:0

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