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Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn’s disease and differentially expressed in goblet cells

Citation

Ranson, N and Veldhuis, M and Mitchell, B and Fanning, S and Cook, AL and Kunde, D and Eri, R, Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn's disease and differentially expressed in goblet cells, Cellular and Molecular Gastroenterology and Hepatology, 6, (1) pp. 110-112. ISSN 2352-345X (2018) [Refereed Article]


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© 2018 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0/

DOI: doi:10.1016/j.jcmgh.2018.03.001

Abstract

A contributing factor in the development of ulcerative colitis (UC) and Crohn’s disease (CD) is aberrant signaling of the innate immune complex known as the inflammasome. The inflammasome regulates the production of interleukin (IL)1b and drives downstream inflammatory pathways. In this study of human tissue (ethics approval: H11930), we provide evidence for the disease-specific up-regulation of NLRP6 transcript and protein in ileal CD and describe an NLRP6-expressing goblet cell (GC) located predominantly in the upper portion of the intestinal crypt.

Item Details

Item Type:Refereed Article
Keywords:colitis, IBD, NLRP6, goblet cells, Crohn's disease
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetic Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
UTAS Author:Ranson, N (Dr Nicole Ranson)
UTAS Author:Cook, AL (Associate Professor Tony Cook)
UTAS Author:Kunde, D (Dr Dale Kunde)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:126842
Year Published:2018
Web of Science® Times Cited:4
Deposited By:Health Sciences
Deposited On:2018-06-27
Last Modified:2019-03-20
Downloads:31 View Download Statistics

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