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NLRP6 Ranson et al., 2018 CMGH published paper.pdf (3.57 MB)

Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn’s disease and differentially expressed in goblet cells

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posted on 2023-05-19, 19:07 authored by Nicole RansonNicole Ranson, Veldhuis, M, Mitchell, B, Fanning, S, Anthony CookAnthony Cook, Kunde, D, Rajaraman Eri
A contributing factor in the development of ulcerative colitis (UC) and Crohn’s disease (CD) is aberrant signaling of the innate immune complex known as the inflammasome. The inflammasome regulates the production of interleukin (IL)1b and drives downstream inflammatory pathways. In this study of human tissue (ethics approval: H11930), we provide evidence for the disease-specific up-regulation of NLRP6 transcript and protein in ileal CD and describe an NLRP6-expressing goblet cell (GC) located predominantly in the upper portion of the intestinal crypt.

Funding

Clifford Craig Foundation

History

Publication title

Cellular and Molecular Gastroenterology and Hepatology

Volume

6

Pagination

110-112

ISSN

2352-345X

Department/School

School of Health Sciences

Publisher

American Gastroenterological Association

Place of publication

United States

Rights statement

© 2018 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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