Saul, A and Taylor, B and Simpson Jr, S and Ponsonby, A-L and Blizzard, L and Dwyer, T and McMorran, B and Wood, B and van der Mei, IAF, Polymorphism in the serotonin transporter gene polymorphisms (5-HTTLPR) modifies the association between significant life events and depression in people with multiple sclerosis, Multiple Sclerosis Journal pp. 1-8. ISSN 1352-4585 (2018) [Refereed Article]
Copyright 2018 the Authors
Objective: We examined the interaction between significant life events (SLE), 5-HTTLPR and depression/anxiety.
Methods: A population-based longitudinal cohort of 198 people with MS was followed biannually for 2.5 years. Depression and anxiety symptoms were measured at each review using the Hospital Anxiety and Depression Scale (HADS). SLEs were assessed using a questionnaire based on the Social Readjustment Rating Scale.
Results: We found an interaction between SLE load in the previous 12 months and functional variation in the 5-HTTLPR allele type in predicting depression, with the association between SLE load and depression being stronger for those with S/S allele type (β = 0.21 (95% confidence interval (CI): 0.09-0.33) per 10-unit increase) and S/L (β = 0.14 (95% CI: 0.05-0.24)) compared to L/L allele type (β = 0.04 (95% CI: -0.05 to 0.24); Pinteraction < 0.001). No convincing evidence of an interaction was found with anxiety.
Conclusion: We found that the association between SLE load and MS depression severity was stronger among those with one or two copies of the short allele of the 5-HTTLPR. The identification of a gene-environment interaction between SLEs and depression in a population where depression is partly disease-driven is novel.
|Item Type:||Refereed Article|
|Keywords:||multiple sclerosis, 5-HTTLPR, anxiety, depression, serotonin-transporter-linked polymorphic region, significant life events, stress|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|UTAS Author:||Saul, A (Miss Alice Saul)|
|UTAS Author:||Taylor, B (Professor Bruce Taylor)|
|UTAS Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|UTAS Author:||Blizzard, L (Professor Leigh Blizzard)|
|UTAS Author:||Wood, B (Mrs Brenda Wood)|
|UTAS Author:||van der Mei, IAF (Associate Professor Ingrid van der Mei)|
|Deposited By:||Menzies Institute for Medical Research|
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